Fig. 2

CircCRIM1 promotes the progression of ovarian cancer in vitro. Ovarian cancer cell line OVCAR3 had a higher expression of circCRIM1 than CAOV3 (a). The over-expression and knockdown plasmids of circCRIM1 were examined by qRT-PCR (b). Enhanced expression of circCRIM1 promoted cell viability, migration, invasion and inhibited apoptosis. CircCRIM1 knockdown had opposite effect (c, d, e and f). Three separate experiments were conducted; data are shown as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001