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Table 2 Proportions of mitochondria with normal or abnormal ultrastructure (using TEM) in cumulus cells and oocytes from all treatment groups at PCCI week 0 and week 6

From: Diet normalization or caloric restriction as a preconception care strategy to improve metabolic health and oocyte quality in obese outbred mice

  Total mitochondria Normal mitochondria Abnormal mitochondria
Oocytes
PCCI week 0 HF_HF 525 347 (66.10%) 178 (33.90%)a
CTRL_CTRL 400 379 (94.75%) 21 (5.25%)b
PCCI week 6 HF_HF 562 301 (53,56%) 261 (46.44%)a
HF_CTRL 442 398 (90.05%) 44 (9.95%)b
HF_CR 586 530 (90.44%) 56 (9.56%)b
CTRL_CTRL 497 482 (96.98%) 15 (3.02%)c
Cumulus cells
PCCI week 0 HF_HF 305 301 (98.69%) 4 (1.31%)
CTRL_CTRL 193 191 (98.96%) 2 (1.04%)
PCCI week 6 HF_HF 446 437 (97.98%) 9 (2.02%)
HF_CTRL 318 312 (98.11%) 6 (1.89%)
HF_CR 429 416 (96.97%) 13 (3.03%)
CTRL_CTRL 504 497 (98.61%) 7 (1.39%)
  1. Data are presented as proportions from total number of mitochondria evaluated, from 3 to 5 COCs per treatment group (from 3 to 5 mice per treatment group). Significant differences between the indicated treatment groups at the same PCCI time point are indicated with letters a, b and c (P < 0.05)