Reproductive Biology and Endocrinology

Table 2 Proportions of mitochondria with normal or abnormal ultrastructure (using TEM) in cumulus cells and oocytes from all treatment groups at PCCI week 0 and week 6

From: Diet normalization or caloric restriction as a preconception care strategy to improve metabolic health and oocyte quality in obese outbred mice

		Total mitochondria	Normal mitochondria	Abnormal mitochondria
Oocytes
PCCI week 0	HF_HF	525	347 (66.10%)	178 (33.90%)^a
PCCI week 0	CTRL_CTRL	400	379 (94.75%)	21 (5.25%)^b
PCCI week 6	HF_HF	562	301 (53,56%)	261 (46.44%)^a
	HF_CTRL	442	398 (90.05%)	44 (9.95%)^b
	HF_CR	586	530 (90.44%)	56 (9.56%)^b
	CTRL_CTRL	497	482 (96.98%)	15 (3.02%)^c
Cumulus cells
PCCI week 0	HF_HF	305	301 (98.69%)	4 (1.31%)
PCCI week 0	CTRL_CTRL	193	191 (98.96%)	2 (1.04%)
PCCI week 6	HF_HF	446	437 (97.98%)	9 (2.02%)
	HF_CTRL	318	312 (98.11%)	6 (1.89%)
	HF_CR	429	416 (96.97%)	13 (3.03%)
	CTRL_CTRL	504	497 (98.61%)	7 (1.39%)

Data are presented as proportions from total number of mitochondria evaluated, from 3 to 5 COCs per treatment group (from 3 to 5 mice per treatment group). Significant differences between the indicated treatment groups at the same PCCI time point are indicated with letters a, b and c (P < 0.05)

Back to article page

ISSN: 1477-7827

Contact us

General enquiries: journalsubmissions@springernature.com