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Table 3 Fertility outcomes in infertile couples according to hrHPV status

From: Impact of human papillomavirus infection on semen parameters and reproductive outcomes

  IVF (n = 161) IUI (n = 53) Spontaneous pregnancy (n = 46)
Pregnancy (%) P-value Abortion (%) P-value Pregnancy (%) P-value Abortion (%) P-value Pregnancy (%) P-value Abortion (%) P-value
hrHPV+ male
 Yes 10/11 (90.9%) 0.051 1/10 (10%) 0.485 3/6 (50%) 1.000 0/3 (0%) 1.000 2/18 (11.1%)a 0.250 0/2 (0%) 1.000
 No 88/150 (58.7%) 5/88 (5.7%) 24/47 (51.1%) 1/24 (4.2%) 44/167 (26.3%)b 5/44 (11.4%)
hrHPV+ female
 Yes 16/20 (80%) 0.103 1/16 (6.2%) 1.000 1/6 (16.7%) 0.100 0/1 (0%) 1.000 9/40 (22.5%)a 0.854 0/9 (0%) 0.566
 No 82/141 (58.2%) 5/82 (6.1%) 26/47 (55.3%) 1/26 (3.8%) 37/145 (25.5%)b 5/37 (13.5%)
hrHPV+ couple
 Yes 2/3 (66.7%) 1.000 0/2 (0%) 1.000 0/1 (0%) 0.491 0/0 (0%) 1.000 0/5 (0%)a 0.436 0/0 (0%) NA
 No 96/158 (60.8%) 6/96 (6.2%) 27/52 (51.9%) 1/27 (3.7%) 46/180 (25.6%)b 5/46 (10.9%)
  1. HrHPV includes HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 70, 73, and 82 genotypes
  2. The P-value was calculated using Pearson’s chi-square test
  3. aAll hrHPV positive male/female partners or whole couple not treated by ART (IVF or IUI)
  4. bAll hrHPV negative male/female partners or whole couple not treated by ART (IVF or IUI)