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Table 3 Fertility outcomes in infertile couples according to hrHPV status

From: Impact of human papillomavirus infection on semen parameters and reproductive outcomes

 

IVF (n = 161)

IUI (n = 53)

Spontaneous pregnancy (n = 46)

Pregnancy (%)

P-value

Abortion (%)

P-value

Pregnancy (%)

P-value

Abortion (%)

P-value

Pregnancy (%)

P-value

Abortion (%)

P-value

hrHPV+ male

 Yes

10/11 (90.9%)

0.051

1/10 (10%)

0.485

3/6 (50%)

1.000

0/3 (0%)

1.000

2/18 (11.1%)a

0.250

0/2 (0%)

1.000

 No

88/150 (58.7%)

5/88 (5.7%)

24/47 (51.1%)

1/24 (4.2%)

44/167 (26.3%)b

5/44 (11.4%)

hrHPV+ female

 Yes

16/20 (80%)

0.103

1/16 (6.2%)

1.000

1/6 (16.7%)

0.100

0/1 (0%)

1.000

9/40 (22.5%)a

0.854

0/9 (0%)

0.566

 No

82/141 (58.2%)

5/82 (6.1%)

26/47 (55.3%)

1/26 (3.8%)

37/145 (25.5%)b

5/37 (13.5%)

hrHPV+ couple

 Yes

2/3 (66.7%)

1.000

0/2 (0%)

1.000

0/1 (0%)

0.491

0/0 (0%)

1.000

0/5 (0%)a

0.436

0/0 (0%)

NA

 No

96/158 (60.8%)

6/96 (6.2%)

27/52 (51.9%)

1/27 (3.7%)

46/180 (25.6%)b

5/46 (10.9%)

  1. HrHPV includes HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 70, 73, and 82 genotypes
  2. The P-value was calculated using Pearson’s chi-square test
  3. aAll hrHPV positive male/female partners or whole couple not treated by ART (IVF or IUI)
  4. bAll hrHPV negative male/female partners or whole couple not treated by ART (IVF or IUI)