UHPLC-MS-MS analysis of oxylipins metabolomics components of follicular fluid in infertile individuals with diminished ovarian reserve

Liang, Chengcheng; Zhang, Xiaole; Qi, Cong; Hu, Hui; Zhang, Qinhua; Zhu, Xiuxian; Fu, Yonglun

doi:10.1186/s12958-021-00825-x

Table 4 Correlation analysis between the concentration of oxidized lipid metabolites and related parameters

From: UHPLC-MS-MS analysis of oxylipins metabolomics components of follicular fluid in infertile individuals with diminished ovarian reserve

Metabolites(ng/ml)	R/P	AGE	FSH	AMH	AFC	OR	MII	FER	HQE
20-HDoHE	R	-0.120	-0.555**	0.426**	0.581**	0.446**	0.457**	0.400*	0.250
20-HDoHE	P	0.461	0.000	0.006	0.000	0.004	0.003	0.010	0.120
±5-iso PGF2α-VI	R	-0.175	-0.455**	0.361*	0.508**	0.361*	0.341	0.273	0.103
±5-iso PGF2α-VI	P	0.286	0.004	0.024	0.001	0.024	0.052	0.093	0.531
12S-HHTrE	R	-0.101	-0.303	0.365*	0.252	0.347*	0.385*	0.361*	0.002
12S-HHTrE	P	0.535	0.057	0.021	0.117	0.028	0.014	0.022	0.989
15-deoxy-Δ12,14-PGJ₂	R	0.024	-0.346*	0.264	0.298	0.144	0.147	0.096	-0.266
15-deoxy-Δ12,14-PGJ₂	P	0.882	0.029	0.099	0.062	0.376	0.365	0.556	0.097
1a,1b-dihomo PGE2	R	-0.147	-0.347*	0.547**	0.425**	0.463**	0.495**	0.497**	0.151
1a,1b-dihomo PGE2	P	0.367	0.028	0.000	0.006	0.003	0.001	0.001	0.351
1a,1b-dihomo PGF2α	R	0.052	-0.148	0.259	0.296	0.223	0.276	0.287	0.056
1a,1b-dihomo PGF2α	P	0.749	0.361	0.107	0.063	0.166	0.084	0.073	0.730
20-COOH-AA	R	-0.022	-0.353*	0.390*	0.362*	0.393*	0.414**	0.425**	0.339*
20-COOH-AA	P	0.892	0.025	0.013	0.022	0.012	0.008	0.006	0.032
20-HETE	R	0.191	-0.386	0.327	0.447	0.510	0.436	0.412	-0.220
20-HETE	P	0.494	0.156	0.234	0.095	0.052	0.104	0.128	0.431
8S,15S-DiHETE	R	-0.023	-0.241	0.509**	0.564**	0.452**	0.377*	0.356*	0.099
8S,15S-DiHETE	P	0.889	0.145	0.001	0.000	0.004	0.020	0.028	0.553
PGA2	R	-0.149	-0.504**	0.511**	0.503**	0.408*	0.424*	0.373*	-0.192
PGA2	P	0.408	0.003	0.002	0.003	0.019	0.014	0.033	0.284
PGD2	R	-0.187	-0.551*	0.009	0.385	0.374	0.482*	0.463*	-0.168
PGD2	P	0.442	0.015	0.972	0.104	0.115	0.037	0.046	0.492
PGE1	R	-0.178	-0.481**	0.559**	0.512**	0.442**	0.437**	0.405*	-0.058
PGE1	P	0.278	0.002	0.000	0.001	0.005	0.005	0.011	0.726
PGF1α	R	-0.085	-0.323	0.278	0.297	0.128	0.131	0.148	-0.287
PGF1α	P	0.644	0.071	0.124	0.099	0.485	0.475	0.418	0.111
PGF2α	R	-0.162	-0.288	0.383*	0.357*	0.344*	0.414**	0.404*	-0.074
PGF2α	P	0.319	0.072	0.015	0.024	0.030	0.008	0.010	0.649
PGJ₂	R	-0.100	-0.330	0.071	0.339	0.014	0.196	0.025	-0.422
PGJ₂	P	0.745	0.271	0.817	0.257	0.964	0.520	0.936	0.151

P, P-value,**P<0.01,*P<0.05; AGE, age; FSH, follicle stimulating hormone; AMH, anti-Mullerian hormone; AFC, antral follicle count; OR, number of oocytes retrieved; MII, number of MII oocytes; FER, number of fertilizations, HQE, number of high-quality embryos

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