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Table 2 Pregnancy and birth outcomes compared between the immediate and delayed FET groups. Data are presented as numbers (%)

From: Immediate versus delayed frozen embryo transfer in women following a failed IVF-ET attempt: a multicenter randomized controlled trial

 

Intention-to-treat analysis

Per-protocol analysis

Immediate FET group

Delayed FET group

Relative risk (95% CI)

P-value

Immediate FET group

Delayed FET group

Relative risk (95% CI)

P-value

Subjects

366

366

  

326

320

  

Positive pregnancy

155 (42.3)

159 (43.4)

0.98 (0.83 to 1.15)

0.765

154 (47.2)

157 (49.1)

0.96 (0.82 to 1.13)

0.643

Embryo implantation

157/620 (25.3)

125/609 (20.5)

1.23 (1.00 to 1.52)

0.046

156/620 (25.2)

123/609 (20.2)

1.25 (1.01 to 1.53)

0.038

Clinical pregnancy a

137 (37.4)

111 (30.3)

1.23 (1.01 to 1.51)

0.042

136 (41.7)

109 (34.1)

1.23 (1.00 to 1.50)

0.045

Biochemical pregnancy loss

18 (11.6)

48 (30.2)

0.39 (0.24 to 0.63)

 < 0.001

18 (11.7)

48 (30.6)

0.28 (0.23 to 0.63)

 < 0.001

Clinical pregnancy loss b

15 (10.9)

13 (11.7)

0.94 (0.47 to 1.88)

0.850

15 (11.0)

12 (11.0)

1.00 (0.49 to 2.05)

0.996

Total pregnancy loss

33 (21.3)

61 (38.4)

0.56 (0.39 to 0.80)

0.001

33 (21.4)

60 (38.2)

0.56 (0.39 to 0.81)

0.001

Ectopic pregnancy

2 (1.3)

5 (3.1)

0.41 (0.08 to 2.08)

0.448

2 (1.3)

5 (3.2)

0.40 (0.08 to 2.04)

0.448

Multiple pregnancy

18 (13.1)

14 (12.6)

1.04 (0.54 to 2.00)

0.902

18 (13.2)

14 (12.8)

1.03 (0.54 to 1.98)

0.928

Ongoing pregnancy

122 (33.3)

98 (26.8)

1.25 (0.99 to 1.56)

0.053

121 (37.1)

97 (30.3)

1.22 (0.99 to 1.52)

0.067

Live birth

120 (32.8)

96 (26.2)

1.25 (0.99 to 1.57)

0.052

119 (36.5)

96 (30.0)

1.22 (0.98 to 1.52)

0.079

  1. Abbreviation: FET Frozen thawed embryo transfer, CI Confidence interval
  2. a In the Immediate FET group, one woman conceived naturally and delivered a healthy male infant vaginally
  3. b In the Delayed FET group, two women conceived spontaneously, however, one miscarried in the second trimester because of fetal anomalies