More blastocysts are produced from fewer oocytes in ICSI  compared to IVF – results from a sibling oocytes study and definition of a new key performance indicator

Chamayou, Sandrine; Ragolia, Carmen; Alecci, Carmelita; Storaci, Giorgia; Romano, Simona; Sapienza, Roberta; Maglia, Elena; Liprino, Annalisa; Cardea, Clementina; Fichera, Michele; Guglielmino, Antonino

doi:10.1186/s12958-021-00804-2

Table 2 Comparison of in vitro results after ICSI and IVF on sibling oocytes in split insemination cycles and according to ovarian stimulation protocol, infertility indication and female age

From: More blastocysts are produced from fewer oocytes in ICSI compared to IVF – results from a sibling oocytes study and definition of a new key performance indicator

	TOTAL	Ovarian stimulation protocol						Infertility									Female age
		Long			Short			Unexplained			Male			Female			19–37 years old			38–45 years old
		ICSI	IVF	p	ICSI	IVF	p	ICSI	IVF	p	ICSI	IVF	p	ICSI	IVF	p	ICSI	IVF	p	ICSI	IVF	p
n. cycles	211	122			89			91			20			100			159			52
n. COCs	2602	571	570		731	730		540	539		128	128		634	633		1034	1033		268	267
n. micro-injected or inseminated MII oocytes	1804	396	395		508	505		374	374		89	89		441	437		717	716		187	184
n. zygotes	1325	330	279		399	317		309	248		69	55		351	293		584	470		145	126
fertilization rate	73.4	83.3	70.6	< 0.001	78.5	62.8	< 0.001	82.6	66.3	< 0.001	77.5	61.8	< 0.05	79.6	67.0	< 0.001	81.5	65.6	< 0.001	77.5	68.5	< 0.05
n. cleaved embryos	1282	326	265		383	308		299	239		65	54		345	280		567	448		142	125
cleavage rate	96.8	98.8	95.0	< 0.01	96.0	97.2	NS	96.8	96.4	NS	94.2	98.2	NS	98.3	95.6	< 0.05	97.1	95.3	NS	97.9	99.2	NS
n. blastocysts	708	222	158		177	151		177	129		39	30		183	150		327	243		72	66
blastocyst rate/ zygote	53.4	67.3	56.6	< 0.01	44.4	47.6	NS	57.3	60.9	NS	56.5	54.5	NS	52.1	51.2	NS	56.0	51.7	NS	49.7	52.4	NS
blastocyst rate/ MII oocyte	39.2	56.1	40.0	< 0.001	34.8	29.9	< 0.05	47.3	24.5	< 0.001	43.8	33.7	NS	41.5	34.3	< 0.05	45.6	33.9	< 0.001	38.5	35.9	NS
n. oocytes per usable blastocyst	2.5	1.8	2.5	< 0.001	2.9	3.3	< 0.05	2.1	2.9	< 0.001	2.3	3.0	< 0.05	2.4	2.9	< 0.05	2.2	2.9	< 0.001	2.6	2.8	NS
n. frozen blastocysts	342	103	47		108	84		96	52		21	13		94	66		190	115		21	16
n. transferred blastocysts	366	119	111		69	67		81	77		18	17		89	84		137	128		51	50
n. implanted blastocysts	149	49	40		31	29		32	30		8	7		40	32		69	58		11	11
implantation rate	40.7	41.2	36.0	NS	44.9	43.3	NS	39.5	39.0	NS	44.4	41.2	NS	44.9	38.1	NS	50.4	45.3	NS	21.6	22.0	NS
n. live births	135	43	37		29	26		31	29		7	5		34	29		63	55		9	8
live birth rate	36.9	36.1	33.3	NS	42.0	38.8	NS	38.3	37.7	NS	38.9	29.4	NS	38.2	34.5	NS	46.0	43.0	NS	17.6	16.0	NS

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ISSN: 1477-7827

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