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Fig. 5 | Reproductive Biology and Endocrinology

Fig. 5

From: Trophoblast derived extracellular vesicles specifically alter the transcriptome of endometrial cells and may constitute a critical component of embryo-maternal communication

Fig. 5

(A) Eleven miRNAs identified as specific to JAr EVs and their corresponding numbers of putative high-confidence (miRDB target score ≥ 90) gene targets present in the RL95 gene expression dataset. Numbers of non-differentially expressed (grey bars), downregulated (blue) and upregulated target genes (orange) are shown. (B) Relationship between abundance of JAr-specific miRNA in JAr EVs (expressed as mean log2cpm, derived from three libraries) and the mean log2FC of downregulated (FDR ≤ 0.05) putative high-confidence targets (target score ≥ 90) in RL95 cells. The number of downregulated putative targets for each miRNA is represented by the point size. Weighted regression line (weighted by number of downregulated targets) with 95% confidence intervals of the mean are shown

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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