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Fig. 5 | Reproductive Biology and Endocrinology

Fig. 5

From: Circular RNA hsa_circ_0081343 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-210-5p/DLX3 axis

Fig. 5

miR-210-5p inhibitor suppresses apoptosis and stimulates migration and invasion of HTR-8 cells. HTR-8 cells were transfected with miR-NC, ov-circ_0081343 + miR-210-5p, and NC + miR-NC. The overexpression of miR-210-5p and hsa_circ_0081343 in three groups was verified by qRT-PCR. The protein levels of MMP2, MMP9, cleaved caspase 3, and cleaved caspase 9 (B), early apoptosis level (C), and the migration and invasion capacities (D) were evaluated by western blot, flow cytometry analysis, and Transwell assays, respectively. *p < 0.05, when compared to ov-circ_0081343 + miR-NC group; * p < 0.05, when compared to miR-NC inhibitor. All experiments were independently performed three times

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