Skip to main content

Table 1 Characteristics of inculded studies

From: GnRH agonist and hCG (dual trigger) versus hCG trigger for follicular maturation: a systematic review and meta-analysis of randomized trials

Author (year) Conflict of interest Ethical approval Time of randomization Time frame Inclusion criteria Exclusion criteria Sample size Intervention Comparison
Haas et al. (2020) [14] None Yes Morning of the trigger day 2016–2018 Age 18–41 y; BMI 18–35 kg/m2; AMH > 1 ng/ml; AFC 6–20; FSH < 20 IU/l; first three IVF cycle E2 levels > 15,000 pmol/l; moderate–severe endometriosis 146 hCG 10,000 IU and GnRH agonist 0.5 mg hCG 10,000 IU and placebo
Mahajan et al. (2016) [21] None Yes NR NR Aged 24–43; AMH < 4 ng/ml; AFCs/ovary < 12 None 76 hCG 5000 IU and GnRH agonist 1 mg hCG 10,000 IU
Ali et al. (2020) [13] None Yes NR 2016–2018 First ICSI cycle; aged less than 40 y; BMI 18–30 kg/m2; AMH > 1 ng/ml; normal, mild or moderate male factor infertility Azoospermic males 160 250 IU of recombinant HCG and GnRH agonist 1 mg 250 IU of recombinant HCG
Schachter et al. (2008) [24] NR Yes Onset of intervention NR Failed at least one IVF-ET cycle on GnRH agonist long protocol; hysterosalpingogram or hysteroscopy history; BMI 18–30 kg/m2; Lack of oocytes aspirated in previous cycles; 211 hCG 5000 IU and GnRH agonist 0.2 mg hCG 5000 IU
Haas et al. (2019) [19] None Yes NR 2015–2017 Poor responders defined with the Bologna criteria. None 23 hCG 6500 IU and GnRH agonist (dose not reported) hCG 6.500 IU
Eftekhar et al. (2017) [20] None Yes Leading follicles reached 17 mm in diameter 2014–2015 Aged less than 42 y; BMI 18–30 kg/m2; moderate ovarian response Endocrine disorders; PCOS; UA; RIF; azoospermia; day-3 FSH ≥ 10 IU/L or AMH ≤1.0 ng/mL 192 hCG 6500 IU and GnRH agonist 0.2 mg hCG 6.500 IU
Kim et al. (2014) [22] NR Yes NR NR Women with regular ovulatory cycles PCOS, metabolic disorders 120 250 μg rhCG and GnRH agonist 0.1 mg 250 μg rhCG and placebo
Decleer et al. (2014) [23] NR Yes NR 2011–2013 Tubal or male infertility, BMI < 32, age ≤ 38 y, frst, second and third IVF cycle. Azospermia, UA, PCOS, endocrine disorders, endometriosis 120 hCG 5000 IU and GnRH agonist 0.2 mg hCG 5000 IU
  1. Abbreviations: NR not reported, NS no special, ET embryo transfer, IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, 2PN two pronuclei, OHSS ovarian hyperstimulation syndrome, PCOS polycystic ovarian syndrome, BMI body mass index, PGT preimplantation genetic screening, RIF repeated implantation failure, UA uterine anomalies, AMH anti-Mullerian Hormone