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Fig. 5 | Reproductive Biology and Endocrinology

Fig. 5

From: Upregulated Talin1 synergistically boosts β-estradiol-induced proliferation and pro-angiogenesis of eutopic and ectopic endometrial stromal cells in adenomyosis

Fig. 5

Talin1 cooperated with β-E2 in facilitating adenomyotic endometrial stromal cell proliferation and angiogenesis a. and b. Overexpression of Talin1 or treatment with β-E2 both promoted cell proliferation of ADS_Eu_ESC and ADS_Ec_ESC; while co-transfection of OV-Talin1 and β-E2 treatment showed the most significant enhanced effect on cell proliferation. c. Tube and network formation assay of HUVEC was performed to examine the angiogenetic ability of ADS_Eu_ESC and ADS_Ec_ESC treated with either OV-Talin1 transfection or β-E2 or both. d.e. Western blot detection of proteins related to cell proliferation and angiogenesis in adenomyotic endometrial stromal cells. GAPDH was used as a loading control. Data were presented as mean ± SD. *P < 0.05, **P < 0.01. OV-NC, negative control for Talin1transfection; OV-Talin1, overexpression of Talin1; β-E2 + OV-Talin1, after being transfected with Talin1 overexpression vector, cells were then treated with β-E2 (10nM)

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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