Extracellular microRNAs: key players to explore the outcomes of in vitro fertilization

Table 4 Predictive values of sensitivity and specificity evaluation for the probability of PCOS

FF miRNAs	Prediction for normo-androgenic PCOS
	AUC [(95% population limit)]	S.E.M	*P-Value	**Cut-off point	Sensitivity (%)	Specificity (%)
miR-7-5p	0.711 [0.63; 0.89]	0.061	0.001	≥ 0.931	63.4	87.1
miR-378-3p	0.620 [0.51; 0.72]	0.053	0.001	≥ 25.1	68.9	88.7
miR-224	0.581 [0.47; 0.68]	0.044	0.001	≥ 0.987	64.8	86.4
miR-202-5p	0.798 [0.59; 0.85]	0.054	0.002	≤ 15.8	71.5	88.5
miR-212-3p	0.726 [0.58; 0.89]	0.064	0.001	≥ 35.14	77.8	87.2
miR-21-5p	0.643 [0.53; 0.76]	0.057	0.003	≤ 41.21	61.5	81.74
Combination of FF miR-7-5p, 202-5p, 378-3p, 224, 212-3p, 21-5p	0.881 [0.61; 0.92]	0.040	0.001	–	79.2	87.32

S. M. E means ± standard error of the mean, *The null hypothesis was true area = 0.5, after adjusting a number of attempts and the number of embryos. P-values in bold letters are considered statistically significant p < 0.05. ** Estimated cut points that maximize sensitivity and specificity for observed range predictors

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