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Table 1 Basic characteristics of the 24 studies included in the review

From: Effect of the time interval between oocyte retrieval and ICSI on embryo development and reproductive outcomes: a systematic review

Author Study design N Protocol for COH O2% Timing control HCG-OPU
(h)
OPU-DN
(h)
DN-ICSI
(h)
OPU-ICSI
(h)
Grouping criteria
Velde et al. (1998 [21]) PS 60 GnRHa NM O 36 1–6 0–4 1–6 Three groups: OPU-DN: 1–2 h, DN-ICSI: 0 h or 4 h; OPU-DN: 1–2 h and DN-ICSI: 0 h or OPU-DN: 5–6 h and DN-ICSI: 0 h; OPU-DN: 1–2 h and DN-ICSI: 4 h or OPU-DN: 5–6 h and DN-ICSI: 0 h
Yanagida et al. (1998) [22] PS 544 GnRHa NM O > 35 1–11 0 1–11 Grouped by OPU-DN: 1–3 h; 3–5 h; 5–7 h; 7–9 h; 9–11 h
Rienzi et al. (1998) [23] RS 95 GnRHa 20% O 36 2–12 0 2–12 Grouped by OPU-DN: ≤3 h; 3–6 h; 6–9 h; 9–12 h
Andrews et al. (2001) [24] RS 1210 GnRHa NM O 36 0–1 Some time 0–5 Grouped by OPU-ICSI: < 3 h; 3–5 h; > 5 h
Hassan et al. (2001) [2] PS 141 GnRHa 20% O NM 0–4 0–4 0–4 Three groups: OPU-DN: 0 h and DN-ICSI: 0 h; OPU-DN: 4 h and DN-ICSI: 0 h; OPU-DN: 0 h and DN-ICSI: 4 h
Jacobs et al. (2001) [25] RS 432 GnRHa 20% O 36 > 0–4 0 > 0–4 Grouped by OPU-DN: 0–2 h; 2–3 h; 3–4 h; > 4 h
Ho et al. (2003) [26] RS 64 GnRHa NM O 34 1–8 0 1–8 Grouped by OPU-DN: < 2.5 h; 2.5–3.5 h; 3.5–4.5; 4.5–5.5; ≥5.5 h
Isiklar et al. (2004) [15] PS 1260 GnRHa 5% O 36 0–4 0 0–4 Grouped by OPU-DN: 0 h; 2–4 h
Falcone et al. (2008) [3] RS 135 GnRHa 20% O > 36 2 0–10 2–12 Grouped by DN-ICS: 2–4 h; 4–5 h; 5–6 h; 6–7 h; 7–8 h; 9–12 h
Boldi et al. (2010) [27] RS Ab 203 NM NM O NM NM 0–3 NM Grouped by DN-ICS: 0 h; 1–3 h
Aletebi (2011) [4] PS 309 GnRHant NM O 36 0–2 0–2 0–4 Three groups: OPU-DN: 0 h and DN-ICSI: 0 h; OPU-DN: 1 h and DN-ICSI: 1 h; OPU-DN: 2 h and DN-ICSI: 2 h
Patrat et al. (2012) [17] RS 110 GnRHa 20% O 36.5 ± 1 0–3 0–3 0–6 Grouped by OPU-DN OR DN-ICSI: 0.5 h as an interval
Esbert et al. (2013) [28] RS Ab 1212 NM NM O NM 2 or 4 NM Within 4.5 Grouped by OPU-DN: 2 h; 4 h
Garor et al. (2015) [5] RS 614 GnRHa/GnRHant NM O 34–38 0.08–7 0.08–5.2 NM Grouped by OPU-DN: < 2 h; > 2 h
Grouped by DN-ICSI: < 1 h; > 1 h
Terasawa et al. (2016) [29] RS Ab 302 MS/NC NM O NM > 0–3 NM NM Grouped by OPU-DN:< 2 h; 2–3 h; > 3 h
Ishikawa et al. (2016) [30] PS Ab 54 NM NM O NM 0–2 NM NM Grouped by OPU-DN: 0 h; 2 h
Pereira et al. (2016) [31] RS 15 GnRHa/GnRHant NM O 35–37 1.9 vs 2.9 NM NM OPU-DN was compared between two groups with first complete fertilisation failure and next successful fertilisation in the same patient
Bárcena et al. (2016) [19] RS 3178 GnRHa/GnRHant 20% A Mostly 36 0.5–3 0.6–10.8 1.4–11.7 Ten groups: grouped by OPU-DN OR DN-ICSI: by deciles
Pujol et al. (2018) [20] RS 1468 GnRHa/GnRHant 20% A 36 0.4–2.12 0.26–11.19 1.0–12.6 Ten groups: grouped by OPU-DN OR DN-ICSI: by deciles
Mizuno et al. (2018) [16] PS 54 GnRHa/GnRHant NM O 36–38 0 or 2 h 2.5–4 2.5–4.5 Grouped by OPU-DN: 0 h; 2 h
Naji et al. (2018) [32] RS 2051 GnRHa/GnRHant 5% A 36 0–5 NM NM Grouped by OPU-DN:< 2 h; 2–5 h
Subgroup analysis: OPU-DN: 0 h; 0.5–2 h
Zhang et al. (2020) [33] RS 3602 GnRHa/GnRHant NM O > 36 2.2 ± 0.8 2.8 ± 1 NM Grouped by DN –ICSI: 0–1 h; 1–2 h; 2–3 h; 3 h–4 h; 4–5 h; > 5 h
Azizi et al. (2020) [34] PS 613 GnRHa/GnRHant NM O 35–39 0.5–6 0–4.8 NM Grouped by OPU-DN: < 2 h; > 2 h
Grouped by DN-ICSI: < 2 h; > 2 h
Maggiulli al. (2020) [35] RS 1444 GnRHa/GnRHant 5% A 34–37 2–7 0 2–7 The relationship between blastocyst formation rate and IO-DN was analysed
  1. RS Retrospective Study, PS Prospective Study, Ab Abstract, NM Not Mentioned, O operator, A Automatically by RI-Witness, MS/NC Mini-stimulation /natural cycles, COH Controlled Ovarian Hyperstimulation, HCG Human Chorionic Gonadotrophin, OPU Oocyte Pick up, DN Denudation, ICSI Intra-cytoplasmic Sperm Injection, GnRHa GnRH agonists ,GnRHant GnRH antagonists