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Table 4 The enriched pathway terms of the up and down regulated differentially expressed genes

From: Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules

Pathway ID

Pathway Name

P-value

FDR B&H

FDR B&Y

Bonferroni

Gene Count

Geness

Up regulated genes

1268678

Translation

8.83E-20

4.54E-17

3.26E-16

6.54E-17

30

RPL24,RPL27,RPL30,RPL29,RPL34,RPL35A,RPL36A,RPLP0,RPS5,RPS8,ETF1,RPS10,EIF3E,RPS15,RPS15A,SRP72,RPS20,RPS21,RPS23,RPS24,RPS29,EIF3L,TRMT112,RPL14,RPS27L,EIF1AX,SEC11A,EIF5,RPL35,RPL13A

1270128

Respiratory electron transport

2.39E-16

1.27E-14

9.10E-14

1.77E-13

22

ETFB,NDUFA2,ECSIT,NDUFB2,NDUFC2,NDUFS4,NDUFS5,UQCRC1,UQCRFS1,UQCRH,UQCR11,COX4I1,COX5B,COX6A1,NDUFAF3,COX6B1,COX6C,COX7C,COX8A,NDUFA13,COX7A2L,UQCRQ

1268677

Metabolism of proteins

6.29E-10

1.46E-08

1.05E-07

4.66E-07

72

B4GALT2,RPL24,RPL27,RPL30,RPL29,UAP1,RPL34,RPL35A,RPL36A,RPLP0,RPS5,PSMB1,RPS8,ETF1,RPS10,PSMB4,ETFB,EIF3E,PSMB7,RPS15,RPS15A,PSMC5,SRP72,PSMD3,RPS20,PFDN1,RPS21,RPS23,PFDN5,PSMD10,RPS24,COA4,RPS29,TOMM5,GFPT1,NEDD8,RAB10,SAA1,UBE2E1,UCHL1,EIF3L,TADA3,RAB4A,TBCA,PMM1,TOMM7,WIPI1,TRMT112,TNIP2,PIGS,AMDHD2,USP24,DERL2,CPE,RPL14,RPS27L,ARF5,EXOC5,TIMM8B,DPH5,ICMT,EIF1AX,ATP6AP2,SEC11A,DYNLL2,EIF5,CHCHD2,SUMO3,RPL35,SYVN1,RPL13A,PSMD14

1269649

Gene Expression

1.72E-09

3.85E-08

2.77E-07

1.27E-06

77

CDKN2B,RPL24,PRPF31,RPL27,RPL30,RPL29,RPL34,RPL35A,RPL36A,PRELID1,TMEM219,RPLP0,SAP18,RPS5,PSMB1,RPS8,ETF1,RPS10,PSMB4,EIF3E,PSMB7,RPS15,RPS15A,PSMC5,NBN,SRP72,PSMD3,RPS20,RPS21,RPS23,PSMD10,RPS24,RPS29,LSM3,RBMX,EIF3L,NABP2,LSM4,PRMT1,TAF7,SRSF6,POLR3GL,RBBP7,COX4I1,TRMT112,COX5B,COX6A1,COX6B1,POLR2J,POLR2K,NELFB,COX6C,COX7C,COX8A,RPL14,TEAD3,SKIL,YWHAH,RPS27L,CCNC,POLR1D,GTF2A2,MED4,GTF3A,LAMTOR4,EIF1AX,ZNF706,SEC11A,SF3B6,EIF5,COX7A2L,HSD17B10,RPL35,RPL13A,PSMD14,SNRPD2,SF3B5

1269852

Autodegradation of Cdh1 by Cdh1:APC/C

1.22E-06

2.58E-05

1.86E-04

9.04E-04

10

PSMB1,PSMB4,PSMB7,PSMC5,PSMD3,PSMD10,UBE2E1,ANAPC5,CDC27,PSMD14

1268843

Mitochondrial translation initiation

2.55E-06

4.96E-05

3.57E-04

1.89E-03

11

MRPL12,MRPS12,MRPS21,MRPL24,MRPL20,MRPL54,MRPS24,MRPS15,MRPS6,MRPS34,MRPL9

Down regulated genes

1269650

Generic Transcription Pathway

1.96E-04

1.10E-01

7.63E-01

1.10E-01

29

ZNF717,ZNF486,ZNF154,ESR1,ZSCAN25,MEN1,ZNF547,BANP,ZNF347,ZNF778,TAF4B,ZNF114,ZNF573,ZNF555,ZNF493,NEDD4L,ZNF596,ZNF689,ZNF300,RFFL,FAS,ZNF496,ZNF334,ZKSCAN3,CHEK2,ZNF528,ZNF543,TOP3A,ZNF124

1269903

Transmembrane transport of small molecules

2.80E-02

7.66E-01

1.00E+00

1.00E+00

18

ATP6V1G2,SLC22A15,SLCO4A1,ASIC3,ABCB4,SLC24A4,SLC44A5,SCNN1D,SLC9A7,ATP13A4,NEDD4L,ATP13A1,ABCC5,SLC1A7,SLC5A4,SLC30A7,NDC1,GABRA4

1268846

Cilium Assembly

3.71E-02

7.66E-01

1.00E+00

1.00E+00

7

SDCCAG8,NPHP4,FBF1,ODF2,WDR19,CEP135,IFT122

1269957

Metabolism of carbohydrates

1.11E-01

7.66E-01

1.00E+00

1.00E+00

8

PRPS2,CHST14,XYLB,MGAM,ABCC5,SLC5A4,NDC1,SLC25A13

1269443

Signalling by NGF

1.63E-01

7.66E-01

1.00E+00

1.00E+00

11

EREG,SPTB,OBSCN,KBTBD7,GFRA3,TIAM2,NGFR,FGFR3,BCL2L11,LCK,TRIB3

1269171

Adaptive Immune System

1.86E-01

7.66E-01

1.00E+00

1.00E+00

17

EREG,LRSAM1,HLA-H,RAP1GAP2,KBTBD7,SLAMF6,HECW2,FGFR3,KIR2DL4,TREML1,LILRA3,NEDD4L,MAP 3K14,KLC2,LCK,TRIB3,LMO7