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Table 4 The enriched pathway terms of the up and down regulated differentially expressed genes

From: Identification of key pathways and genes in polycystic ovary syndrome via integrated bioinformatics analysis and prediction of small therapeutic molecules

Pathway ID Pathway Name P-value FDR B&H FDR B&Y Bonferroni Gene Count Geness
Up regulated genes
1268678 Translation 8.83E-20 4.54E-17 3.26E-16 6.54E-17 30 RPL24,RPL27,RPL30,RPL29,RPL34,RPL35A,RPL36A,RPLP0,RPS5,RPS8,ETF1,RPS10,EIF3E,RPS15,RPS15A,SRP72,RPS20,RPS21,RPS23,RPS24,RPS29,EIF3L,TRMT112,RPL14,RPS27L,EIF1AX,SEC11A,EIF5,RPL35,RPL13A
1270128 Respiratory electron transport 2.39E-16 1.27E-14 9.10E-14 1.77E-13 22 ETFB,NDUFA2,ECSIT,NDUFB2,NDUFC2,NDUFS4,NDUFS5,UQCRC1,UQCRFS1,UQCRH,UQCR11,COX4I1,COX5B,COX6A1,NDUFAF3,COX6B1,COX6C,COX7C,COX8A,NDUFA13,COX7A2L,UQCRQ
1268677 Metabolism of proteins 6.29E-10 1.46E-08 1.05E-07 4.66E-07 72 B4GALT2,RPL24,RPL27,RPL30,RPL29,UAP1,RPL34,RPL35A,RPL36A,RPLP0,RPS5,PSMB1,RPS8,ETF1,RPS10,PSMB4,ETFB,EIF3E,PSMB7,RPS15,RPS15A,PSMC5,SRP72,PSMD3,RPS20,PFDN1,RPS21,RPS23,PFDN5,PSMD10,RPS24,COA4,RPS29,TOMM5,GFPT1,NEDD8,RAB10,SAA1,UBE2E1,UCHL1,EIF3L,TADA3,RAB4A,TBCA,PMM1,TOMM7,WIPI1,TRMT112,TNIP2,PIGS,AMDHD2,USP24,DERL2,CPE,RPL14,RPS27L,ARF5,EXOC5,TIMM8B,DPH5,ICMT,EIF1AX,ATP6AP2,SEC11A,DYNLL2,EIF5,CHCHD2,SUMO3,RPL35,SYVN1,RPL13A,PSMD14
1269649 Gene Expression 1.72E-09 3.85E-08 2.77E-07 1.27E-06 77 CDKN2B,RPL24,PRPF31,RPL27,RPL30,RPL29,RPL34,RPL35A,RPL36A,PRELID1,TMEM219,RPLP0,SAP18,RPS5,PSMB1,RPS8,ETF1,RPS10,PSMB4,EIF3E,PSMB7,RPS15,RPS15A,PSMC5,NBN,SRP72,PSMD3,RPS20,RPS21,RPS23,PSMD10,RPS24,RPS29,LSM3,RBMX,EIF3L,NABP2,LSM4,PRMT1,TAF7,SRSF6,POLR3GL,RBBP7,COX4I1,TRMT112,COX5B,COX6A1,COX6B1,POLR2J,POLR2K,NELFB,COX6C,COX7C,COX8A,RPL14,TEAD3,SKIL,YWHAH,RPS27L,CCNC,POLR1D,GTF2A2,MED4,GTF3A,LAMTOR4,EIF1AX,ZNF706,SEC11A,SF3B6,EIF5,COX7A2L,HSD17B10,RPL35,RPL13A,PSMD14,SNRPD2,SF3B5
1269852 Autodegradation of Cdh1 by Cdh1:APC/C 1.22E-06 2.58E-05 1.86E-04 9.04E-04 10 PSMB1,PSMB4,PSMB7,PSMC5,PSMD3,PSMD10,UBE2E1,ANAPC5,CDC27,PSMD14
1268843 Mitochondrial translation initiation 2.55E-06 4.96E-05 3.57E-04 1.89E-03 11 MRPL12,MRPS12,MRPS21,MRPL24,MRPL20,MRPL54,MRPS24,MRPS15,MRPS6,MRPS34,MRPL9
Down regulated genes
1269650 Generic Transcription Pathway 1.96E-04 1.10E-01 7.63E-01 1.10E-01 29 ZNF717,ZNF486,ZNF154,ESR1,ZSCAN25,MEN1,ZNF547,BANP,ZNF347,ZNF778,TAF4B,ZNF114,ZNF573,ZNF555,ZNF493,NEDD4L,ZNF596,ZNF689,ZNF300,RFFL,FAS,ZNF496,ZNF334,ZKSCAN3,CHEK2,ZNF528,ZNF543,TOP3A,ZNF124
1269903 Transmembrane transport of small molecules 2.80E-02 7.66E-01 1.00E+00 1.00E+00 18 ATP6V1G2,SLC22A15,SLCO4A1,ASIC3,ABCB4,SLC24A4,SLC44A5,SCNN1D,SLC9A7,ATP13A4,NEDD4L,ATP13A1,ABCC5,SLC1A7,SLC5A4,SLC30A7,NDC1,GABRA4
1268846 Cilium Assembly 3.71E-02 7.66E-01 1.00E+00 1.00E+00 7 SDCCAG8,NPHP4,FBF1,ODF2,WDR19,CEP135,IFT122
1269957 Metabolism of carbohydrates 1.11E-01 7.66E-01 1.00E+00 1.00E+00 8 PRPS2,CHST14,XYLB,MGAM,ABCC5,SLC5A4,NDC1,SLC25A13
1269443 Signalling by NGF 1.63E-01 7.66E-01 1.00E+00 1.00E+00 11 EREG,SPTB,OBSCN,KBTBD7,GFRA3,TIAM2,NGFR,FGFR3,BCL2L11,LCK,TRIB3
1269171 Adaptive Immune System 1.86E-01 7.66E-01 1.00E+00 1.00E+00 17 EREG,LRSAM1,HLA-H,RAP1GAP2,KBTBD7,SLAMF6,HECW2,FGFR3,KIR2DL4,TREML1,LILRA3,NEDD4L,MAP 3K14,KLC2,LCK,TRIB3,LMO7
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Reproductive Biology and Endocrinology

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