Table 3 The enriched GO terms of the up and down regulated differentially expressed genes

GO:0006518

BP

peptide metabolic process

1.51E-13

2.66E-11

2.37E-10

6.37E-10

52

RPL24,RPL27,RPL30,RPL29,RPL34,RPL35A,RPL36A,RPLP0,MRPL12,MRPS12,RPS5,RPS8,ETF1,RPS10,EIF3E,RPS15,RPS15A,SRP72,RPS20,RPS21,RPS23,RPS24,RPS29,EIF6,EIF3L,MRPS21,MRPL24,MRPL20,COA3,RBM3,TRMT112,MRPL54,CPE,RPL14,RPS27L,EIF2D,DPH5,EIF1AX,ATP6AP2,ZNF706,SEC11A,MRPS24,UHMK1,EIF5,MRPS15,MRPS6,MRPS34,LSM14A,RPL35,RPL13A,MRPL9,RSL24D1

GO:0006886

BP

intracellular protein transport

6.75E-12

8.16E-10

7.28E-09

2.86E-08

66

GIPC1,SNAPIN,RPL24,TCTN3,RPL27,RPL30,RPL29,RPL34,ROMO1,RPL35A,RPL36A,RPLP0,RPS5,RPS8,RPS10,RPS15,RPS15A,PHB2,SRP72,RPS20,HMGCL,RPS21,RPS23,RPS24,RPS29,ARFIP2,TOMM5,EIF6,RAB10,ATP6V1D,SNX8,PEX19,AGFG1,PEX2,ZFAND6,RABGEF1,SNX9,RAB4A,PMM1,TOMM7,SRSF6,ANP32B,RPAIN,TNPO2,DERL2,FIS1,RPL14,APOD,ECH1,IFI27,YWHAH,TMED4,ARF5,NDUFA13,EXOC5,EIF2D,UBL5,TIMM8B,ICMT,UHMK1,DYNLL2,VPS28,RPL35,SYVN1,RPL13A,STX10

GO:0031967

CC

organelle envelope

2.36E-19

1.71E-17

1.20E-16

1.47E-16

72

ROMO1,PRELID1,MRPL12,MRPS12,PET100,BAK1,PHB2,LRRC59,HMGCL,GCHFR,COA4,NDUFA2,SLC25A26,BLOC1S1,ECSIT,SUCLG1,NDUFB2,TOMM5,NDUFC2,BANF1,MOAP1,NDUFS4,NDUFS5,PHB,BNIP3,PI4KB,FDX1,MRPS21,AGFG1,SLC25A11,TMEM97,UQCRC1,UQCRFS1,UQCRH,UQCR11,NME2,MRPL24,CERS2,MRPL20,TOMM7,COA3,COX4I1,COX5B,DTYMK,ANXA4,COX6A1,NDUFAF3,COX6B1,MRPL54,COX6C,COX7A2,COX7C,COX8A,FIS1,IFI27,MAD2L1BP,CCND2,NDUFA13,CYB5B,TMEM256,TIMM8B,AIFM1,MRPS24,MRPS15,CHCHD2,MRPS6,MRPS34,COX7A2L,UQCRQ,HSD17B10,MTDH,MRPL9

GO:1902494

CC

catalytic complex

1.31E-12

5.84E-11

4.09E-10

8.17E-10

67

PRPF31,DCAF6,ERH,SAP18,OST4,PSMB1,PSMB4,ETFB,PSMB7,PSMC5,PSMD3,PSMD10,NDUFA2,EZH1,SUCLG1,NDUFB2,NDUFC2,NDUFS4,NDUFS5,LSM3,CKS1B,TSPAN17,SLC9A3R1,UBE2E1,RBMX,MORF4L1,PEX2,AK1,PRMT1,UQCRC1,UQCRFS1,UQCRH,TAF7,ANAPC5,TADA3,ANAPC13,RBX1,CUL4A,POLR3GL,RBBP7,PIGS,POLR2J,POLR2K,DERL2,BCCIP,POLE4,NAA38,CCNC,CCND2,RMRP,NDUFA13,POLR1D,GTF2A2,ORMDL1,SEC11A,SF3B6,DYNLL2,SMARCD2,UQCRQ,HSD17B10,KLHL12,SYVN1,CDC27,PSMD14,SNRPD2,RPPH1,KRTCAP2

GO:0003723

MF

RNA binding

1.66E-10

4.49E-08

3.30E-07

1.45E-07

76

RPL24,PRPF31,RPL27,RPL30,RPL29,RPL34,RPL35A,RPL36A,ERH,RPLP0,MRPL12,MRPS12,SAP18,RSL1D1,RPS5,RPS8,ETF1,RPS10,EIF3E,RPS15,RPS15A,SRP72,RPS20,LRRC59,RPS21,RPS23,RPS24,SUCLG1,EIF6,LSM3,RBMX,EIF3L,MRPS21,NQO1,AGFG1,LSM4,PRMT1,SLC25A11,TBCA,MRPL20,NUDT16,SRSF6,S100A16,GLRX3,RBBP7,RBM3,MRPL54,NELFB,BCCIP,RDX,RPL14,C7orf50,XRCC5,SERPINH1,RPS27L,EIF2D,GTF3A,FAM32A,EIF1AX,SBDS,SF3B6,MRPS24,UHMK1,EIF5,MRPS15,SLTM,MRPS6,LSM14A,HSD17B10,RPL35,RPL13A,SNRPD2,MTDH,MRPL9,SF3B5,RSL24D1

GO:0008134

MF

transcription factor binding

1.05E-02

1.83E-01

1.00E+00

1.00E+00

23

NAB1,PHB2,PSMC5,FAM89B,NBN,PSMD10,MDFI,TAF7,SETD3,TADA3,RBX1,WIPI1,ANXA4,TEAD3,IFI27,YWHAH,GTF2A2,MED4,ICMT,CHCHD2,HSD17B10,MTDH,TRIB1

GO:0120036

BP

plasma membrane bounded cell projection organization

7.28E-05

2.19E-02

1.94E-01

2.91E-01

49

EPHB4,STK36,MAK,SPAST,ZFYVE27,TTLL3,MYO7A,MYO10,SDCCAG8,SPTB,SARM1,RAP1GAP2,NPHP4,GFRA3,AMIGO1,HECW2,GLI2,GLI3,SYNE2,WRAP73,NGFR,NTN1,NLGN2,FGFR3,PLD1,CEP126,NYAP1,DNAH5,UBXN10,PLXNB3,SEMA6B,FAT4,NPTX1,NEDD4L,STXBP5,FBF1,LAMA5,RFFL,ODF2,FAS,RFX3,ATL1,TRAK1,WDR19,FEZ1,AVIL,CEP135,IFT122,EPHA4

GO:0000902

BP

cell morphogenesis

3.10E-03

1.93E-01

1.00E+00

1.00E+00

31

EPHB4,CDH26,SPAST,ZFYVE27,MYO7A,MYO10,CDHR3,SPTB,SARM1,GFRA3,AMIGO1,HECW2,GLI2,GLI3,NGFR,NTN1,FGFR3,NYAP1,PLXNB3,SEMA6B,NPTX1,NEDD4L,STXBP5,LAMA5,CDH19,ATL1,TRAK1,WDR19,FEZ1,C8orf37,EPHA4

GO:0043005

CC

neuron projection

3.65E-05

7.26E-03

5.00E-02

2.00E-02

46

EPHB4,MAK,PDE4B,SNPH,SPAST,ZFYVE27,MYO7A,MYO10,ESR1,SDCCAG8,SARM1,RAP1GAP2,N4BP3,NPHP4,SNAP47,TIAM2,AMIGO1,KCNC1,PTPRN2,SYNJ2,NGFR,NLGN2,BSN,NPTX1,CALCR,PLXDC1,STXBP5,ERO1A,GRK4,AAK1,APBA1,KLC2,VTI1A,FAS,ATL1,TRAK1,WDR19,SHISA9,FEZ1,KCNQ4,AVIL,UNC13C,IFT122,CTNND1,EPHA4,GABRA4

GO:0030054

CC

cell junction

3.04E-03

8.34E-02

5.74E-01

1.00E+00

34

CDH26,SNPH,CDHR3,SDCCAG8,SARM1,OBSCN,NPHP4,ABCB4,ARHGAP22,RASIP1,PTPRN2,SYNE2,LPXN,NGFR,NLGN2,FGFR3,BSN,FHL3,CDC42BPA,PLXDC1,STXBP5,FBF1,LCK,CDH19,CLDN1,PRIMA1,SHISA9,LMO7,CTNNA3,UNC13C,C8orf37,CTNND1,EPHA4,GABRA4

GO:0000981

MF

DNA-binding transcription factor activity, RNA polymerase II-specific

9.75E-04

3.67E-01

1.00E+00

7.35E-01

43

ZNF717,ZXDC,HIVEP1,ERG,ZNF154,ESR1,ZSCAN25,ARNTL2,ZNF836,ZNF469,ZNF547,GLI2,GLI3,ZNF347,ZNF778,BATF3,TET3,ZNF687,ZNF114,MACC1,ZNF555,ZNF493,FOXP2,NRL,ZNF596,ZNF689,ZNF300,ZKSCAN2,RFX3,ZNF496,IKZF4,RLF,KAT7,DMRT2,ZNF334,MTF1,ZKSCAN3,ZNF559-ZNF177,ZNF69,ZNF528,ZNF543,GLIS1,ZNF124

GO:0005524

MF

ATP binding

2.83E-02

4.14E-01

1.00E+00

1.00E+00

34

EPHB4,PRPS2,STK36,MAK,CNNM2,SPAST,TTLL3,MYO7A,MYO10,NEK10,OBSCN,PFAS,TOR4A,ABCB4,FGFR3,XYLB,DNAH5,DNHD1,ATP13A4,DNAH3,CDC42BPA,ATP13A1,GRK4,MAP 3K14,AAK1,ABCC5,LCK,NLRP2,NLRP6,TRIB3,CHEK2,ERCC6L2,MAST3,EPHA4