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Fig. 5 | Reproductive Biology and Endocrinology

Fig. 5

From: Down‐regulation of the Sp1 transcription factor by an increase of microRNA-4497 in human placenta is associated with early recurrent miscarriage

Fig. 5

miRNA-4497 induced trophoblast apoptosis by targeting SP1. (a) Effect of miRNA-4497 on trophoblast cell apoptosis was detected by apoptosis assay. miRNA-4497 overexpression significantly induced trophoblasts apoptosis. (b) Western blotting was used to detect the effect of SP1-siRNA on the expression of SP1. Transfection of SP1-siRNA into trophoblast significantly reduced the SP1 protein expression. (c) Effect of SP1 on trophoblasts apoptosis was detected by apoptosis assay. SP1 under-expression led to an increased percentage of apoptotic cells in HTR-8/SVneo culture. *, P<0.05; ***, P<0.001

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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