Non-coding RNAs in polycystic ovary syndrome: a systematic review and meta-analysis

Mu, Liangshan; Sun, Xiaoting; Tu, Mixue; Zhang, Dan

doi:10.1186/s12958-020-00687-9

Reproductive Biology and Endocrinology

Table 5 List of ncRNAs observed in PCOS

From: Non-coding RNAs in polycystic ovary syndrome: a systematic review and meta-analysis

ncRNAs	Detected in cell/tissue	Expression	Target gene(s)/acting pathway	Reported function(s)	References
miR-93	Adipose tissue	↑	GLUT4	Correlated with insulin resistance	[26]
	Granulose cells	↑	CDKN1A	Promotes proliferation and cell cycle progression	[27]
	Granulose cells	↑	SMAD7 and TGFBR2	Impaired follicle development	[49]
	Plasma	↑	NGF Signalling and HGF Signalling	Correlated with insulin resistance	[32]
miR-320	Serum	↓	Through ET-1 regulating ERK1/2 signalling pathway	Promotes cell mitosis	[44]
	Cumulus cells	↓	RUNX2	Estrogen deficiency	[58]
	Ovarian tissue	↓	Through IRS-1 regulating ERK1/2 signalling pathway	Inhibits insulin resistance	[72]
	Follicular fluid	↓	RAB5B	Correlated with insulin resistance	[25]
	Follicular fluid, granulosa cells	↑	E2F1 and SF-1	Inhibited estradiol release and cell proliferation; enhanced progesterone synthesis	[46]
miR-9	Follicular fluid	↑	IRS2, SYT1, IL8	Mediates the effects of insulin; steroid synthesis	[45]
miR-18b	Follicular fluid	↑	IRS2, SYT1, IL8	Mediates the effects of insulin; steroid synthesis	[45]
miR-135a	Follicular fluid	↑	IRS2, SYT1, IL8	Mediates the effects of insulin; steroid synthesis	[45]
	Granulosa cells	↑	ESR2	Promoted proliferation and inhibited apoptosis	[67]
miR-186	Granulosa cells	↑	ESR2	Promoted proliferation and inhibited apoptosis	[67]
miR-21	Serum	↑	LATS1	Promotes secondary follicle growth	[31]
miR-21	Granulose cells	↑	SMAD7 and TGFBR2	Impaired follicle development	[49]
miR-592	Serum	↓	LHCGR	Inhibited cell viability and cell cycle progression	[33]
miR-92a	Ovarian theca interna tissues	↓	GATA-6 and IRS-2	Related to androgenic and insulin signaling pathways	[17]
miR-223	Plasma	↑	PPAR, IGF-1 and angiopoietin signaling	Correlated with insulin resistance hyperandrogenism, endometrial response and ovarian follicle development	[32]
miR-483	Ovary cortex	↓	IGF1	Inhibits cell proliferation	[71]
miR-483-5p	Cumulus granulosa cells	↓	Notch3 and MAPK3	Related to cell proliferation and apoptosis	[55]
miR-483-5p	Cumulus cells	↓	IGF2	Inhibits insulin resistance	[53]
miR-486-5p	Cumulus cells	↓	PI3K/Akt	Promote cumulus cell proliferation	[53]
miR-509-3p	Cumulus cells	↑	MAP3K8	Improved oestradiol secretion	[56]
miR-6767-5p	Serum	↓		Negatively associated with fasting glucose	[36]
miR-145	Granulosa cells	↓	IRS1	Negatively Regulates Cell Proliferation	[57]
miR-126-5p	Granulosa cells	↓	Klotho-associated signaling	Involved in apoptosis of cells	[60]
miR-29a-5p	Granulosa cells	↓	Klotho-associated signaling	Involved in apoptosis of cells	[60]
miR-27a-3p	Granulosa cells	↑	SMAD5	Decreased cell proliferation and promoted cell apoptosis	[61]
miR-335-5p	Follicular fluid	↓	SGK3	Involved in granulosa cells proliferation	[51]
miR-873-5p	Follicular fluid	↑	Heme oxygenase-1 (HO-1)	Involved in apoptosis of cells	[52]
miR-19b	Granulosa cells	↓	IGF-1	Promotes cell proliferation	[62]
miR-99a	Granulosa cells	↑	IGF-1	Regulates proliferation and apoptosis	[63]
miR-33b	Granulosa cells	↑	TGFBR1	Induced dysregulated cell proliferation, apoptosis, and cell cycle	[64]
miR-142	Granulosa cells	↑	TGFBR1	Induced dysregulated cell proliferation, apoptosis, and cell cycle	[64]
miR-423	Granulosa cells	↓	SMAD7	Induced dysregulated cell proliferation, apoptosis, and cell cycle	[64]
miR-23a	Granulosa cells	↑	SIRT1	Promotes cell apoptosis	[65]
miR-130b-3p	Ovarian theca cells	↑	DENND1A Variant 2	Correlated with androgen biosynthesis	[73]
lncRNA CTBP1-AS	Peripheral blood leukocytes	↑		Reguletes androgen receptor AR activity	[79]
lncRNA SRA	Peripheral blood leukocytes	↑		Promote activity of steroid receptors	[80]
lncRNA PWRN2	Cumulus cells	↑	miR-92b-3p and TMEM120B	Correlated with oocyte nuclear maturation	[83]
lncRNA GAS5	Serum	↓		Correlated with insulin resistance,cell apoptosis and proliferation	[85]
lncRNA BANCR	Granulosa cells	↑	Bax and p53	promote apoptosis	[87]
lncRNA LINC-01572:28	Luteinized granulosa cells	↑	SKP2 and p27	inhibits cell proliferation and cell cycle	[86]
lncRNA H19	Peripheral blood leukocytes	↑		correlated with fasting plasma glucose levels	[88]

Abbreviations: TGFBR1 transforming growth factor beta receptor 1, NGF nerve growth factor, HGF hepatic growth factor, ET-1 endothelin-1, IRS1 insulin receptor substrate 1, IRS insulin receptor substrate, SYT1 synaptogamin 1, IL8 interleukin 8, LATS1 large tumor suppressor, LHCGR luteinizing hormone/chorionic gonadotropin receptor, GATA6 GATA-binding factor 6, IRS-2 insulin receptor substrate proteins 2, PPAR peroxisome proliferator receptor, IGF-1 insulin like growth factor-1, SGK3 serum/glucocorticoid-regulated kinase family member 3, ↑ the expression of ncRNAs was upregulated, ↓ the expression of ncRNAs was downregulated

Back to article page

ISSN: 1477-7827

Contact us

General enquiries: journalsubmissions@springernature.com