Table 1 Characteristics of meta-analysis studies

Wang-1, 2018, [16]

China

46

Before = 44,603.28

After = 37,712.91

50 mg/m² intramuscularly two times (Day 0 and Day 4) MTX

Age (years) = 31.15 ± 5.59

Intraoperative blood loss (ml) = 55.33 ± 44.19

Hospital stay (days) = 9.59 ± 2.46

Gestational age (day) = 48.96 ± 8.27

Number of cesarean deliveries = 1.17 ± 0.383

Fetal heart beat positive, n = 21

High

Wang-2, 2018, [16]

China

14

Before = 25,648.86

After = 31,005.21

intravenously for 5 days (Day 0 to Day 5) MTX

Age (years) = 34.14 ± 4.86

Intraoperative blood loss (ml) = 42.86 ± 22.68

Hospital stay (days) = 13.86 ± 3.88

Gestational age (day) = 52.15 ± 7.94

Number of cesarean deliveries = 1.57 ± 0.514

Fetal heart beat positive, n = 5

High

Giampaolino, 2018, [17]

Italy

19

Before = 1790

After = 35,034

50 mg/m² intramuscularly One times MTX+ D&C

Age (years) = 32.68 ± 3.92

Gestational age (day) = 50.47 ± 4.43

Complication, n = 0

High

Jiang, 2011, [18]

China

45

After = 28,717

50 mg/m² intramuscularly One times MTX

Age (years) = 34.46 ± 5.19

Intraoperative blood loss (ml) = 706.89 ± 642.08

Time for serum-hCG normalization (days) = 20.62 ± 5.41

Complication, n = 3

Success% = 93.3

High

Shen, 2012, [19]

China

46

intravascularly One times MTX

Age (years) = 32.7 ± 6.0

Hospital stay (days) = 10.5 ± 1.0

Time for serum-hCG normalization (days) = 37.7 ± 4.8

Time for CSP mass disappearance (days) = 33.3 ± 4.3

Gestational age (day) = 55.5 ± 2.4

Complication, n = 1

Success% = 97.8

High

Qi, 2015, [20]

China

22

After = 45,710

UAE + MTX + 50 mg/m² Intramuscular

Intraoperative blood loss (ml) = 80.25 ± 113.92

Time for serum-hCG normalization (days) = 31.18 ± 14.80

Gestational age (day) = 59.86 ± 17.67

Complication, n = 4

Success% = 77.3

Medium

Gao, 2014, [21]

China

119

Before = 45,321.50

After = 43,586

D&C + MTX + 50 mg/m² Intramuscular

Intraoperative blood loss (ml) = 261.0 ± 357.4

Hospital stay (days) = 14.6 ± 9.2

Time for serum-hCG normalization (days) = 40.5 ± 17.2

Gestational age (day) = 48.4 ± 7.6

Number of cesarean deliveries = 1.2 ± 0.4

Fetal heart beat positive, n = 8

Complication, n = 10

Success% = 91.6

Gravidity = 3.9 ± 1.6

Parity = 1.4 ± 0.6

High

Liu, 2016, [22]

China

26

Before = 8242

After=

MTX-curettage + Intramuscular (50 mg/m² body surface area)

Age (years) = 31.82 ± 4.80

Intraoperative blood loss (ml) = 335

Hospital stay (days) = 19.38

Time for serum-hCG normalization (days) = 56.15 ± 15.99

Gestational age (day) = 48.4 ± 7.6

Fetal heart beat positive, n = 8

Complication, n = 4

Success% = 84.6

High

Cao, 2018, [23]

China

36

UAE + MTX + 40 mg/m² Intramuscular

Age (years) = 33.46 ± 4.47

Intraoperative blood loss (ml) = 11.44 ± 4.87

Hospital stay (days) = 5.39 ± 1.02

Time for serum-hCG normalization (days) = 34

Complication, n = 3

Success% = 91.7

High

Feng, 2016, [24]

China

11

UAE + MTX + 50 mg/m² Intramuscular

Age (years) = 32.20 ± 4.83

Intraoperative blood loss (ml) = 16 ± 3.8

Time for serum-hCG normalization (days) = 27

Complication, n = 0

Success% = 95.8

High

Sevket, 2014, [25]

Turkey

11

MTX-curettage + Intramuscular

Hospital stay (days) = 14.45 ± 4.96

Complication, n = 0

Success% = 95.8

Medium

Fadhlaoui, 2012, [26]

Tunisia

1

50 mg/m² intramuscularly two times (Day 0 and Day 4) MTX

Age (years) = 35

Hospital stay (days) = 8

Time for serum-hCG normalization (days) = 34

Complication, n = 0

Medium

Wang, 2009, [27]

China

21

After = 13,576

D&C + MTX + Intramuscular

Age (years) = 33.4 ± 4.8

Time for serum-hCG normalization (days) = 38

Complication, n = 5

Success% = 76.2

High

Abdelazim, 2017, [28]

Kazakhstan

1

Multi-dose MTX+ Intramuscular

Age (years) = 37

Hospital stay (days) = 4

Fetal heart beat positive, n = 8

Complication, n = 0

High

Uludag-1, 2016, [29]

Turkey

17

Before = 27,970

After = 11,010

local methotrexate injection

Age (years) = 32.76 ± 5.25

Hospital stay (days) = 7.05 ± 2.77

Complication, n = 0

Success% = 97.2

High

Uludag-2, 2016, [29]

Turkey

27

Before = 7606

After = 4725

systemic methotrexate

Age (years) = 31.07 ± 4.17

Hospital stay (days) = 11.96 ± 4.02

Complication, n = 0

Success% = 98.2

High

Ko, 2015, [30]

China

10

Before = 50,666

intralesional methotrexate

Age (years) = 34.9 ± 4.8

Complication, n = 2

Success% = 80.0

High

Yin, 2014, [31]

China

22

Before = 40,154.17

After = 2531.56

intramuscularly two times (Day 0 and Day 4) MTX

Age (years) = 28.5 ± 3.9

Intraoperative blood loss (ml) = 139 ± 4.83

Hospital stay (days) = 25 ± 6.61

Gestational age (day) = 56.14 ± 21.12

Complication, n = 1

Success% = 95.5

High

Cok, 2015, [32]

Turkey

18

Before = 12,699

local methotrexate injection

Age (years) = 33.7 ± 3.4

Complication, n = 3

Success% = 83.3

High

Timor-Tritsch, 2015, [33]

USA

33

MTX + 50 mg/m² Intramuscular

Complication, n = 1

Success% = 93.9

Medium

Yamaguchi, 2014, [34]

Japan

8

Before = 45,823

local MTX injection

Age (years) = 32.3 ± 4.1

Time for serum-hCG normalization (days) = 78.5

Complication, n = 0

Success% = 94.4

High

Seow, 2013, [35]

China

11

Before = 20,520

After = 22,500

One injection of Intramuscular MTX

Age (years) = 33.8 ± 4.0

Time for serum-hCG normalization (days) = 48

Gestational age (day) = 35 ± 21

Complication, n = 0

Success% = 95.8

High

Li, 2012, [36]

China

28

Before = 26,426

After=

low-dose methotrexate-curettage + Intramuscular

Age (years) = 31.2 ± 2.2

Complication, n = 0

Success% = 96.2

High

Jurkovic, 2003, [37]

UK

6

Before = 36,388

After = 25,000

local injection of 25 mg/m² methotrexate

Age (years) = 39.4 ± 3.8

Complication, n = 2

Success% = 66.7

High

Pirjani −1, 2015, [38]

Iran

1

Local MTX + Systemic MTX

Age (years) = 35

Time for serum-hCG normalization (days) = 56

Gestational age (day) = 84

Fetal heart beat positive, n = 0

Complication, n = 0

Success% = 92.9

Medium

Pirjani −2, 2015, [38]

Iran

1

Systemic MTX + Local MTX

Age (years) = 37

Time for serum-hCG normalization (days) = 35

Gestational age (day) = 35

Fetal heart beat positive, n = 1

Complication, n = 0

Success% = 92.9

Medium