Skip to main content

Table 3 Overall, modifier and ethnic subgroup summary effects of the LD2 and LD3 PON variants with PCOS

From: Paraoxonase single nucleotide variants show associations with polycystic ovary syndrome: a meta-analysis

SNV group
Comparison
Genetic model number of cases/controls (pre-outlier)
n Test of association Test of heterogeneity n Test of association Test of heterogeneity
OR 95% CI Pa PHET I2 (%) Analysis model OR 95% CI Pa PHET I2 (%) Analysis model
Pre-outlier Post-outlier
LD2
Overall (2006/1652)
  Recessive 9 1.33 0.93–1.88 0.11 0.0001 77 Random 6 1.34 1.09–1.64 0.005 0.21 30 Fixed
  Dominant 9 1.09 0.90–1.31 0.37 0.02 56 Random 7 1.16 1.02–1.33 0.03 0.18 32 Fixed
  Codominant 9 1.16 0.96–1.40 0.12 0.0001 80 Random 6 1.14 1.03–1.26 0.01 0.61 0 Fixed
Powera (1448/1169)
  Recessive 3 0.77 0.62–0.97 0.02 0.15 48 Fixed
  Dominant 3 0.93 0.81–1.06 0.27 0.12 52 Fixed
  Codominant 3 0.90 0.74–1.09 0.28 0.04 70 Random 2 0.82 0.72–0.93 0.002 0.63 0 Fixed
Asian (1794/1484)
  Recessive 5 1.05 0.78–1.42 0.73 0.08 55 Random 3 1.22 0.97–1.55 0.09 0.81 0 Fixed
  Dominant 5 1.04 0.91–1.18 0.59 0.39 1 Fixed
  Codominant 5 1.03 0.93–1.13 0.59 0.12 49 Fixed
Caucasian (118/108)
  Recessive 3 1.91 0.94–3.89 0.08 0.08 61 Random 2 1.39 0.89–2.18 0.15 0.52 0 Fixed
  Dominant 3 1.25 0.87–1.78 0.22 0.84 0 Fixed
  Codominant 3 1.32 1.05–1.67 0.02 0.46 0 Fixed
LD3
Overall (516/424)
  Recessive 4 1.02 0.74–1.40 0.91 0.05 63 Random 3 1.2 0.95–1.51 0.12 0.59 0 Fixed
  Dominant 4 0.94 0.82–1.07 0.32 0.44 0 Fixed
  Codominant 4 0.97 0.84–1.12 0.66 0.08 56 Random 3 1.04 0.93–1.17 0.49 0.75 0 Fixed
  1. SNV single nucleotide variant, LD linkage disequilibrium, LD2 (rs705379 + rs7493 + rs854572), LD3 (rs854571+ rs854572 + rs854573 + rs705381), PON Paraoxonase, PCOS polycystic ovary syndrome; a statistical power ≥ 80%; n number of studies, OR odds ratio, CI confidence interval, Pa P-value for association, PHET P-value for heterogeneity, I2 measure of variability; values in bold indicate significant association