Table 3 Overall, modifier and ethnic subgroup summary effects of the LD2 and LD3 PON variants with PCOS
SNV group Comparison Genetic model number of cases/controls (pre-outlier) | n | Test of association | Test of heterogeneity | n | Test of association | Test of heterogeneity | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | Pa | PHET | I2 (%) | Analysis model | OR | 95% CI | Pa | PHET | I2 (%) | Analysis model | |||
Pre-outlier | Post-outlier | |||||||||||||
LD2 | ||||||||||||||
 Overall (2006/1652) | ||||||||||||||
  Recessive | 9 | 1.33 | 0.93–1.88 | 0.11 | 0.0001 | 77 | Random | 6 | 1.34 | 1.09–1.64 | 0.005 | 0.21 | 30 | Fixed |
  Dominant | 9 | 1.09 | 0.90–1.31 | 0.37 | 0.02 | 56 | Random | 7 | 1.16 | 1.02–1.33 | 0.03 | 0.18 | 32 | Fixed |
  Codominant | 9 | 1.16 | 0.96–1.40 | 0.12 | 0.0001 | 80 | Random | 6 | 1.14 | 1.03–1.26 | 0.01 | 0.61 | 0 | Fixed |
 Powera (1448/1169) | ||||||||||||||
  Recessive | 3 | 0.77 | 0.62–0.97 | 0.02 | 0.15 | 48 | Fixed | – | – | – | – | – | – | – |
  Dominant | 3 | 0.93 | 0.81–1.06 | 0.27 | 0.12 | 52 | Fixed | – | – | – | – | – | – | – |
  Codominant | 3 | 0.90 | 0.74–1.09 | 0.28 | 0.04 | 70 | Random | 2 | 0.82 | 0.72–0.93 | 0.002 | 0.63 | 0 | Fixed |
 Asian (1794/1484) | ||||||||||||||
  Recessive | 5 | 1.05 | 0.78–1.42 | 0.73 | 0.08 | 55 | Random | 3 | 1.22 | 0.97–1.55 | 0.09 | 0.81 | 0 | Fixed |
  Dominant | 5 | 1.04 | 0.91–1.18 | 0.59 | 0.39 | 1 | Fixed | – | – | – | – | – | – | – |
  Codominant | 5 | 1.03 | 0.93–1.13 | 0.59 | 0.12 | 49 | Fixed | – | – | – | – | – | – | – |
 Caucasian (118/108) | ||||||||||||||
  Recessive | 3 | 1.91 | 0.94–3.89 | 0.08 | 0.08 | 61 | Random | 2 | 1.39 | 0.89–2.18 | 0.15 | 0.52 | 0 | Fixed |
  Dominant | 3 | 1.25 | 0.87–1.78 | 0.22 | 0.84 | 0 | Fixed | – | – | – | – | – | – | – |
  Codominant | 3 | 1.32 | 1.05–1.67 | 0.02 | 0.46 | 0 | Fixed | – | – | – | – | – | – | – |
LD3 | ||||||||||||||
 Overall (516/424) | ||||||||||||||
  Recessive | 4 | 1.02 | 0.74–1.40 | 0.91 | 0.05 | 63 | Random | 3 | 1.2 | 0.95–1.51 | 0.12 | 0.59 | 0 | Fixed |
  Dominant | 4 | 0.94 | 0.82–1.07 | 0.32 | 0.44 | 0 | Fixed | – | – | – | – | – | – | – |
  Codominant | 4 | 0.97 | 0.84–1.12 | 0.66 | 0.08 | 56 | Random | 3 | 1.04 | 0.93–1.17 | 0.49 | 0.75 | 0 | Fixed |