Table 1 Expression and clinical application of cirRNAs related to diseases in the reproductive system
Reproduction diseases | Circular RNA | Regulation of the expression in reproductive diseases | miRNA | Biology function | References |
|---|---|---|---|---|---|
Ovarian Endometriosis | circ_0004712 | Up | miR-503 | Induce apoptosis and cell cycle arrest, as well as inhibits ovarian endometrial stromal cell proliferation, angiogenesis, and contraction. | [84] |
circ_0002918 | Up | miR-503 | |||
circ_0008951 | Up | miR-29c | Inhibition of cell proliferation and invasion. | [82] | |
Repeated Implantation Failure | hsa_circRNA_103716、 | Up | hsa-miR-574-5p | miR-574-5p overexpression inhibits cervical cancer growth and metastasis. | [86] |
hsa_circRNA_ 070616 | Up | hsa-miR-574-5p | miR-574-5p overexpression inhibits cervical cancer growth and metastasis. | [86] | |
circRNA-9119 | Up | miR-26a | miR-26a downregulates the expression of Ptgs2 in endometrial epithelial cells (EECS) of dairy gpredicted targets. | [87] | |
Recurrent spontaneous abortion (RSA) | hsa_circRNA_104792 | Down | miR-133a | Used as RSA biomarkers. | [88] |