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Table 1 Expression and clinical application of cirRNAs related to diseases in the reproductive system

From: Biogenesis and functions of circular RNAs and their role in diseases of the female reproductive system

Reproduction diseases Circular RNA Regulation of the expression in reproductive diseases miRNA Biology function References
Ovarian Endometriosis circ_0004712 Up miR-503 Induce apoptosis and cell cycle arrest, as well as inhibits ovarian endometrial stromal cell proliferation, angiogenesis, and contraction. [84]
circ_0002918 Up miR-503
circ_0008951 Up miR-29c Inhibition of cell proliferation and invasion. [82]
Repeated Implantation Failure hsa_circRNA_103716、 Up hsa-miR-574-5p miR-574-5p overexpression inhibits cervical cancer growth and metastasis. [86]
hsa_circRNA_ 070616 Up hsa-miR-574-5p miR-574-5p overexpression inhibits cervical cancer growth and metastasis. [86]
circRNA-9119 Up miR-26a miR-26a downregulates the expression of Ptgs2 in endometrial epithelial cells (EECS) of dairy gpredicted targets. [87]
Recurrent spontaneous abortion (RSA) hsa_circRNA_104792 Down miR-133a Used as RSA biomarkers. [88]