Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis

Aliakbari, Fereshteh; Pouresmaeili, Farkhondeh; Eshghifar, Nahal; Zolghadr, Zahra; Azizi, Faezeh

doi:10.1186/s12958-020-00649-1

Reproductive Biology and Endocrinology

Table 1 Summary of the included studies

From: Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis

NO.	Author (Year)	Country	Ethnicity	Case/Control	Genotyping method	HWE^a
1	Bezold 2001 [22]	Germany	Caucasian	255/200	NA	Yes
2	L. Stuppia 2003 [23]	Italy	Caucasian	93/105	PCR-RFLP	Yes
3	Ebisch 2003 [24]	Netherlands	Caucasian	77/113	PCR-RFLP	Yes
4	Park 2005 [25]	Korea	Asian	373/396	PCR-RFLP	Yes
5	Lee 2006 [26]	China	Asian	373/396	PCR-RFLP	Yes
6	Raman 2005 [27]	India	Asian	151/200	PCR-RFLP	Yes
7	Paracchini 2006 [28]	Italy	Caucasian	59/46	PCR-RFLP	Yes
8	Taioli 2006 [28]	Italy	Caucasian	59/56	PCR-RFLP	Yes
9	Lee 2006 [26]	Korea	Asian	360/325	PCR-RFLP	Yes
10	ZC 2007 [29]	China	Asian	355/252	PCR-RFLP; Sequencing	Yes
11	Zhang 2007 [29]	China	Asian	355/252	PCR-RFLP	Yes
12	Dhillon 2007 [30]	India	Asian	179/200	PCR-RFLP	Yes
13	Tetik A 2008 [31]	Turkey	Asian	100/50	Real-Time PCR	Yes
14	Ravel 2009 [32]	France	Caucasian	252/114	PCR-RFLP	Yes
15	Farcas 2009 [33]	Romania	Caucasian	66/67	PCR-RFLP	Yes
16	Yang 2010 [34]	Australia	Caucasian	131/29	NA	Yes
17	Rejender 2011 [18, 35]	India	Asian	522/315	Sequencing	Yes
18	Safarinejad 2011 [36]	Iran	Asian	164/328	PCR-RFLP	Yes
19	Gava 2011 [37]	Brazil	Latin	156/233	Real-Time PCR	Yes
21	Vani 2012 [38]	India	Asian	266/230	PCR-RFLP	Yes
22	Eloualid 2012 [39]	Spain	Caucasian	344/690	PCR-RFLP	Yes/No
23	Balkan 2013 [40]	Turkey	Asian	108/125	Real-Time PCR	Yes
24	Stangler 2013 [41]	Slovenia	Caucasian	100/111	Multiplex PCR	Yes
25	Sadiq 2014 [42]	Jordan	Asian	150/150	PCR-RFLP	Yes
26	Mahdi 2014 [43]	India	Asian	637/364	PCR-RFLP	Yes
27	Colagar 2014 [10]	Iran	Asian	118/132	PCR-RFLP	Yes
28	Jiang 2014 [44]	China	Asian	215/133	NA	Yes
29	Weiner 2014 [45]	Russia	Caucasian	271/301	Multiplex PCR	Yes
30	Kurzawski 2015 [6]	Poland	Caucasian	284/352	Real-Time PCR	Yes
31	Jiang 2015 [46]	China	Asian	296/204	SNaPshot multiplex system	Yes
32	Momenzadeh 2015 [9]	Iran	Asian	131/130	PCR-RFLP	Yes
33	Irfan 2016 [22]	Pakistan	Asian	437/218	PCR-RFLP	Yes
34	Wang 2017 [47]	China	Asian	1759/1826	PCR-RFLP	Yes
35	Najafipour 2017 [48, 49]	Iran	Asian	280/120	Sequencing	Yes
36	Mazhar 2018 [50]	Pakistan	Asian	232/114	PCR-RFLP	Yes/No
37	Murphy 2011 [51]	Swede	Caucasian	153/184	competitive allele-specific PCR	Yes

^aHardy–Weinberg equilibrium

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