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Table 1 Summary of the included studies

From: Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis

NO. Author (Year) Country Ethnicity Case/Control Genotyping method HWEa
1 Bezold 2001 [22] Germany Caucasian 255/200 NA Yes
2 L. Stuppia 2003 [23] Italy Caucasian 93/105 PCR-RFLP Yes
3 Ebisch 2003 [24] Netherlands Caucasian 77/113 PCR-RFLP Yes
4 Park 2005 [25] Korea Asian 373/396 PCR-RFLP Yes
5 Lee 2006 [26] China Asian 373/396 PCR-RFLP Yes
6 Raman 2005 [27] India Asian 151/200 PCR-RFLP Yes
7 Paracchini 2006 [28] Italy Caucasian 59/46 PCR-RFLP Yes
8 Taioli 2006 [28] Italy Caucasian 59/56 PCR-RFLP Yes
9 Lee 2006 [26] Korea Asian 360/325 PCR-RFLP Yes
10 ZC 2007 [29] China Asian 355/252 PCR-RFLP; Sequencing Yes
11 Zhang 2007 [29] China Asian 355/252 PCR-RFLP Yes
12 Dhillon 2007 [30] India Asian 179/200 PCR-RFLP Yes
13 Tetik A 2008 [31] Turkey Asian 100/50 Real-Time PCR Yes
14 Ravel 2009 [32] France Caucasian 252/114 PCR-RFLP Yes
15 Farcas 2009 [33] Romania Caucasian 66/67 PCR-RFLP Yes
16 Yang 2010 [34] Australia Caucasian 131/29 NA Yes
17 Rejender 2011 [18, 35] India Asian 522/315 Sequencing Yes
18 Safarinejad 2011 [36] Iran Asian 164/328 PCR-RFLP Yes
19 Gava 2011 [37] Brazil Latin 156/233 Real-Time PCR Yes
21 Vani 2012 [38] India Asian 266/230 PCR-RFLP Yes
22 Eloualid 2012 [39] Spain Caucasian 344/690 PCR-RFLP Yes/No
23 Balkan 2013 [40] Turkey Asian 108/125 Real-Time PCR Yes
24 Stangler 2013 [41] Slovenia Caucasian 100/111 Multiplex PCR Yes
25 Sadiq 2014 [42] Jordan Asian 150/150 PCR-RFLP Yes
26 Mahdi 2014 [43] India Asian 637/364 PCR-RFLP Yes
27 Colagar 2014 [10] Iran Asian 118/132 PCR-RFLP Yes
28 Jiang 2014 [44] China Asian 215/133 NA Yes
29 Weiner 2014 [45] Russia Caucasian 271/301 Multiplex PCR Yes
30 Kurzawski 2015 [6] Poland Caucasian 284/352 Real-Time PCR Yes
31 Jiang 2015 [46] China Asian 296/204 SNaPshot multiplex system Yes
32 Momenzadeh 2015 [9] Iran Asian 131/130 PCR-RFLP Yes
33 Irfan 2016 [22] Pakistan Asian 437/218 PCR-RFLP Yes
34 Wang 2017 [47] China Asian 1759/1826 PCR-RFLP Yes
35 Najafipour 2017 [48, 49] Iran Asian 280/120 Sequencing Yes
36 Mazhar 2018 [50] Pakistan Asian 232/114 PCR-RFLP Yes/No
37 Murphy 2011 [51] Swede Caucasian 153/184 competitive allele-specific PCR Yes
  1. aHardy–Weinberg equilibrium