Fig. 2

Experimental operation flow chart. First, we used WGL-MPS technology to detect the CCRs in maternal chromosomes. Secondly, we used PCR to verify the corresponding breakpoints of the 11 embryos generated by serial oocyte verification. Third, we performed PGT-A testing on the selected 3 embryos, and finally obtained an embryo with the same CCRs as the mother. Finally, we transplanted a screened qualified embryo and a normal phenotype baby with the same CCRs as its mother was born