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Table 2 Results of overall and subgroup analyses for FSHR gene polymorphisms and POI

From: Effects of FSHR polymorphisms on premature ovarian insufficiency in human beings: a meta-analysis

Population Sample size
Case/Control
Dominant comparison Recessive comparison Additive comparison Allele comparison
P value OR (95% CI) I2 statistic P value OR (95% CI) I2 statistic P value OR (95% CI) I2 statistic P value OR (95% CI) I2 statistic
rs6165 A/G
 Overall (FEM) 590/1170 0.05 0.77 (0.60–1.00) 18% 0.26 1.23 (0.86–1.76) 11% 0.25 1.16 (0.90–1.48) 7% 0.07 0.87 (0.74–1.01) 3%
 Overall (REM) 590/1170 0.12 0.79 (0.58–1.06) 18% 0.24 1.28 (0.85–1.93) 11% 0.34 1.14 (0.87–1.48) 7% 0.07 0.86 (0.74–1.01) 3%
 Asian (FEM) 136/549 0.72 0.92 (0.58–1.46) 64% 0.13 0.52 (0.22–1.22) 0% 0.20 1.36 (0.85–2.16) 63% 0.86 0.97 (0.71–1.33) 51%
 Asian (REM) 136/549 0.68 0.83 (0.34–2.01) 64% 0.20 0.56 (0.23–1.35) 0% 0.35 1.50 (0.64–3.48) 63% 0.72 0.92 (0.58–1.45) 51%
 Caucasian (FEM) 149/179 0.81 1.08 (0.57–2.04) 19% 0.85 1.08 (0.51–2.28) NA 0.71 0.89 (0.49–1.63) 22% 0.89 0.98 (0.71–1.34) 0%
 Caucasian (REM) 149/179 0.92 0.95 (0.31–2.89) 19% 0.85 1.08 (0.51–2.28) NA 0.94 1.05 (0.32–3.41) 22% 0.90 0.98 (0.71–1.35) 0%
rs6166 A/G
 Overall (FEM) 640/1333 0.52 0.92 (0.73–1.17) 0% 0.29 0.84 (0.61–1.16) 0% 0.16 1.18 (0.94–1.48) 9% 0.87 1.01 (0.88–1.17) 0%
 Overall (REM) 640/1333 0.54 0.93 (0.73–1.18) 0% 0.39 0.86 (0.62–1.20) 0% 0.19 1.18 (0.92–1.50) 9% 0.89 1.01 (0.87–1.17) 0%
 Asian (FEM) 295/846 0.08 0.76 (0.55–1.03) 0% 0.12 0.69 (0.43–1.10) 0% 0.005 1.55 (1.14–2.09) 0% 0.46 0.93 (0.75–1.14) 0%
 Asian (REM) 295/846 0.68 0.83 (0.34–2.01)
64%
  0.20 0.56 (0.23–1.35) 0% 0.005 1.55 (1.14–2.09) 0% 0.45 0.92 (0.75–1.14) 0%
 Caucasian (FEM) 144/175 0.62 1.18 (0.61–2.27) NA 0.85 1.08 (0.51–2.28) NA 0.52 0.82 (0.44–1.53) NA 0.99 1.00 (0.72–1.37) 0%
 Caucasian (REM) 144/175 0.62 1.18 (0.61–2.27) NA 0.85 1.08 (0.51–2.28) NA 0.52 0.82 (0.44–1.53) NA 0.99 1.00 (0.72–1.37) 0%
  1. The values in bold represent there is statistically significant differences between cases and controls
  2. Abbreviations: OR Odds ratio, CI Confidence interval, NA Not available