Table 2 Results of overall and subgroup analyses for FSHR gene polymorphisms and POI
From: Effects of FSHR polymorphisms on premature ovarian insufficiency in human beings: a meta-analysis
Population | Sample size Case/Control | Dominant comparison | Recessive comparison | Additive comparison | Allele comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P value | OR (95% CI) | I2 statistic | P value | OR (95% CI) | I2 statistic | P value | OR (95% CI) | I2 statistic | P value | OR (95% CI) | I2 statistic | ||
rs6165 A/G | |||||||||||||
 Overall (FEM) | 590/1170 | 0.05 | 0.77 (0.60–1.00) | 18% | 0.26 | 1.23 (0.86–1.76) | 11% | 0.25 | 1.16 (0.90–1.48) | 7% | 0.07 | 0.87 (0.74–1.01) | 3% |
 Overall (REM) | 590/1170 | 0.12 | 0.79 (0.58–1.06) | 18% | 0.24 | 1.28 (0.85–1.93) | 11% | 0.34 | 1.14 (0.87–1.48) | 7% | 0.07 | 0.86 (0.74–1.01) | 3% |
 Asian (FEM) | 136/549 | 0.72 | 0.92 (0.58–1.46) | 64% | 0.13 | 0.52 (0.22–1.22) | 0% | 0.20 | 1.36 (0.85–2.16) | 63% | 0.86 | 0.97 (0.71–1.33) | 51% |
 Asian (REM) | 136/549 | 0.68 | 0.83 (0.34–2.01) | 64% | 0.20 | 0.56 (0.23–1.35) | 0% | 0.35 | 1.50 (0.64–3.48) | 63% | 0.72 | 0.92 (0.58–1.45) | 51% |
 Caucasian (FEM) | 149/179 | 0.81 | 1.08 (0.57–2.04) | 19% | 0.85 | 1.08 (0.51–2.28) | NA | 0.71 | 0.89 (0.49–1.63) | 22% | 0.89 | 0.98 (0.71–1.34) | 0% |
 Caucasian (REM) | 149/179 | 0.92 | 0.95 (0.31–2.89) | 19% | 0.85 | 1.08 (0.51–2.28) | NA | 0.94 | 1.05 (0.32–3.41) | 22% | 0.90 | 0.98 (0.71–1.35) | 0% |
rs6166 A/G | |||||||||||||
 Overall (FEM) | 640/1333 | 0.52 | 0.92 (0.73–1.17) | 0% | 0.29 | 0.84 (0.61–1.16) | 0% | 0.16 | 1.18 (0.94–1.48) | 9% | 0.87 | 1.01 (0.88–1.17) | 0% |
 Overall (REM) | 640/1333 | 0.54 | 0.93 (0.73–1.18) | 0% | 0.39 | 0.86 (0.62–1.20) | 0% | 0.19 | 1.18 (0.92–1.50) | 9% | 0.89 | 1.01 (0.87–1.17) | 0% |
 Asian (FEM) | 295/846 | 0.08 | 0.76 (0.55–1.03) | 0% | 0.12 | 0.69 (0.43–1.10) | 0% | 0.005 | 1.55 (1.14–2.09) | 0% | 0.46 | 0.93 (0.75–1.14) | 0% |
 Asian (REM) | 295/846 | 0.68 | 0.83 (0.34–2.01) 64% |  | 0.20 | 0.56 (0.23–1.35) | 0% | 0.005 | 1.55 (1.14–2.09) | 0% | 0.45 | 0.92 (0.75–1.14) | 0% |
 Caucasian (FEM) | 144/175 | 0.62 | 1.18 (0.61–2.27) | NA | 0.85 | 1.08 (0.51–2.28) | NA | 0.52 | 0.82 (0.44–1.53) | NA | 0.99 | 1.00 (0.72–1.37) | 0% |
 Caucasian (REM) | 144/175 | 0.62 | 1.18 (0.61–2.27) | NA | 0.85 | 1.08 (0.51–2.28) | NA | 0.52 | 0.82 (0.44–1.53) | NA | 0.99 | 1.00 (0.72–1.37) | 0% |