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Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model

Fig. 3

Metabolites in the amino acid biosynthesis, and riboflavin and nitrogen metabolism pathways are decreased in endometriosis tissue and endometrium. a) Carnitine (p = 0.002) and b) creatine phosphate (p = 0.01), were decreased in endometriosis tissue (EMO) compared to endometrium from clinically healthy nonhuman primates (NHPs) (nEM). c) Nicotinamide adenine dinucleotide (NADH) was decreased in EMO compared to nEM (p = 0.0001). d) Malic acid, was decreased in EMO (p = 0.005) and endometrium from NHPs with endometriosis (EM) (p = 0.03). e) Flavin adenine dinucleotide (FAD) and f) tryptophan concentrations were also decreased in EMO (FAD, p = 0.001; tryptophan, p = 0.0009) and EM (FAD, p = 0.004; tryptophan, p = 0.0004) compared to nEM. One-way ANOVA, p < 0.05 was considered significant. Carnitine and NADH data were back-transformed from natural log and square root, respectively. For all graphs, sample sizes were nEM, n = 8; EM, n = 12; and EMO, n = 17

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