Expression of the plasminogen system in the physiological mouse ovary and in the pathological polycystic ovary syndrome (PCOS) state

Table 2 Comparisons of whole ovarian IHC staining of markers assessed in PCOS and control mice ovaries

Marker	PCOS/ Controls	N	Mean Total Area (Sum Area) (μm²)(× 10³)	Percentage of Staining (Area fraction ROI) (%)	Average Intensity of Staining (Mean Colour Intensity)
PAI-1	Controls	6	281 ± 264	7.86 ± 5.96	178.27 ± 6.79
	PCOS	6	323 ± 266	13.90 ± 10.57	177.07 ± 8.40
tPA	Controls	6	17 ± 22	0.63 ± 0.79	172.90 ± 6.02
	PCOS	6	8 ± 10	0.29 ± 0.38	169.73 ± 4.20
uPA	Controls	6	227 ± 174	7.61 ± 5.72	164.58 ± 6.57
	PCOS	6	155 ± 125	6.86 ± 5.37	163.43 ± 4.04
Plasminogen/Plasmin NBP2–19859	Controls	6	271 ± 183	7.21 ± 4.09	178.95 ± 3.18
Plasminogen/Plasmin NBP2–19859	PCOS	6	193 ± 79	8.64 ± 3.53	180.70 ± 6.25
Plasminogen NB300–544	Controls	6	1147 ± 1092	38.93 ± 23.14	165.16 ± 5.09
Plasminogen NB300–544	PCOS	6	936 ± 646	41.10 ± 23.38	162.72 ± 8.75

Mean ± SD are represented for all values. PAI-1, plasminogen activator inhibitor-1; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator; ROI, region of interest; N = number of mice ovarian sections or number of mice evaluated (one ovarian section per mouse)

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