Prediction of the lower serum anti-Müllerian hormone threshold for ovarian stimulation prior to in-vitro fertilization using the Elecsys® AMH assay: a prospective observational study

Table 3 Receiver operator characteristics curve analysis

	AUC	95% CI	p-value*	Optimal cut-off value	Sensitivity	Specificity
Failure to reach classical hCG criteria (n = 60)
AMH	0.76^a	0.66-0.85	< 0.001	4.0 pmol/L	53%	89%
AFC	0.79^a	0.70-0.88	< 0.001	7	63%	78%
Model AFC & AMH	0.80^a	0.72–0.89	< 0.001
Cycle cancellation (n = 5)
AMH	0.92^a	0.80-1.00	< 0.001	1.5 pmol/L	80%	96%
AFC	0.92^a	0.86-0.99	< 0.001	4	60%	91%
Model AFC & AMH	0.95^a	0.86–1.00	< 0.001
Low oocyte yield (n = 57)
AMH	0.81^b	0.73-0.89	< 0.001	4.0 pmol/L	54%	88%
AFC	0.68^b	0.57-0.78	< 0.001	5	38%	88%
Model AFC & AMH	0.81^b	0.71–0.88	< 0.001
Embryo transfer (n = 70)
AMH	0.66^a	0.55-0.77	0.005	4.2 pmol/L	72%	46%
AFC	0.63^a	0.51-0.74	0.030	6	83%	41%
Model AFC & AMH	0.65^a	0.54–0.76	0.009
Positive hCG test (n = 26)
AMH	0.60^a	0.46-0.73	0.154	4.4 pmol/L	73%	40%
AFC	0.50^a	0.36-0.63	0.952	6	73%	25%
Model AFC & AMH	0.61^a	0.48–0.75	0.087
Live birth (n = 15)
AMH	0.66^a	0.50-0.82	0.047	3.8 pmol/L	93%	31%
AFC	0.53^a	0.36-0.70	0.750	6	80%	26%
Model AFC & AMH	0.70^a	0.55–0.85	0.008

AUC: area under the curve; CI: confidence interval; AMH: anti-Müllerian hormone; AFC: antral follicle count
*Null-hypothesis: true AUC = 0.5
^aNo statistically significant difference between AFC and AMH ROC-curves
^bStatistical significant difference between AFC and AMH ROC-curves p = 0.004

ISSN: 1477-7827