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Table 3 Receiver operator characteristics curve analysis

From: Prediction of the lower serum anti-Müllerian hormone threshold for ovarian stimulation prior to in-vitro fertilization using the Elecsys® AMH assay: a prospective observational study

  AUC 95% CI p-value* Optimal cut-off value Sensitivity Specificity
Failure to reach classical hCG criteria (n = 60)
 AMH 0.76a 0.66-0.85 < 0.001 4.0 pmol/L 53% 89%
 AFC 0.79a 0.70-0.88 < 0.001 7 63% 78%
 Model AFC & AMH 0.80a 0.72–0.89 < 0.001    
Cycle cancellation (n = 5)
 AMH 0.92a 0.80-1.00 < 0.001 1.5 pmol/L 80% 96%
 AFC 0.92a 0.86-0.99 < 0.001 4 60% 91%
 Model AFC & AMH 0.95a 0.86–1.00 < 0.001    
Low oocyte yield (n = 57)
 AMH 0.81b 0.73-0.89 < 0.001 4.0 pmol/L 54% 88%
 AFC 0.68b 0.57-0.78 < 0.001 5 38% 88%
 Model AFC & AMH 0.81b 0.71–0.88 < 0.001    
Embryo transfer (n = 70)
 AMH 0.66a 0.55-0.77 0.005 4.2 pmol/L 72% 46%
 AFC 0.63a 0.51-0.74 0.030 6 83% 41%
 Model AFC & AMH 0.65a 0.54–0.76 0.009    
Positive hCG test (n = 26)
 AMH 0.60a 0.46-0.73 0.154 4.4 pmol/L 73% 40%
 AFC 0.50a 0.36-0.63 0.952 6 73% 25%
 Model AFC & AMH 0.61a 0.48–0.75 0.087    
Live birth (n = 15)
 AMH 0.66a 0.50-0.82 0.047 3.8 pmol/L 93% 31%
 AFC 0.53a 0.36-0.70 0.750 6 80% 26%
 Model AFC & AMH 0.70a 0.55–0.85 0.008    
  1. AUC: area under the curve; CI: confidence interval; AMH: anti-Müllerian hormone; AFC: antral follicle count
  2. *Null-hypothesis: true AUC = 0.5
  3. aNo statistically significant difference between AFC and AMH ROC-curves
  4. bStatistical significant difference between AFC and AMH ROC-curves p = 0.004