Skip to main content

Table 2 LT4 supplementation and pregnancy outcomes following IVF/ICSI, in women with SCH and/or TAI, without combining the study by Kim et al.

From: Effect of levothyroxine supplementation on pregnancy outcomes in women with subclinical hypothyroidism and thyroid autoimmuneity undergoing in vitro fertilization/intracytoplasmic sperm injection: an updated meta-analysis of randomized controlled trials

Subgroup

Number of studies

Number of patients

Statistical method

Effect size

I2 (%)

Clinical pregnancy

3

723

RR (Random, 95% CI)

1.49 (0.75, 2.94)

90

Live birth

3

723

RR (Random, 95% CI)

2.11 (0.76, 5.84)

88

Miscarriage

3

723

RR (Random, 95% CI)

0.53 (0.35, 0.82)

0

Preterm birth

1

567

RR (Random, 95% CI)

1.13 (0.65, 1.96)

N/A

  1. SCH subclinical hypothyroidism; TAI thyroid autoimmunity; RR risk ratio; CI confidence interval; N/A not available