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Table 2 LT4 supplementation and pregnancy outcomes following IVF/ICSI, in women with SCH and/or TAI, without combining the study by Kim et al.

From: Effect of levothyroxine supplementation on pregnancy outcomes in women with subclinical hypothyroidism and thyroid autoimmuneity undergoing in vitro fertilization/intracytoplasmic sperm injection: an updated meta-analysis of randomized controlled trials

Subgroup Number of studies Number of patients Statistical method Effect size I2 (%)
Clinical pregnancy 3 723 RR (Random, 95% CI) 1.49 (0.75, 2.94) 90
Live birth 3 723 RR (Random, 95% CI) 2.11 (0.76, 5.84) 88
Miscarriage 3 723 RR (Random, 95% CI) 0.53 (0.35, 0.82) 0
Preterm birth 1 567 RR (Random, 95% CI) 1.13 (0.65, 1.96) N/A
  1. SCH subclinical hypothyroidism; TAI thyroid autoimmunity; RR risk ratio; CI confidence interval; N/A not available