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Table 3 Analyses of factors affecting clinical pregnancy rate in poor ovarian responders

From: Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study

  Univariate analysis Multivariate analysis
OR (95% CI) p value Adjusted OR (95% CI) p value
DHEA
 Yes vs. No 4.08(1.50–11.11) 0.006 4.93(1.68–14.53) 0.004
Age (years) 0.91(0.81–1.02) 0.114 0.95(0.84–1.09) 0.466
BMI (kg/m2) 1.05(0.93–1.20) 0.397   
Infertility duration 0.90(0.79–1.03) 0.120 0.88(0.76–1.03) 0.106
Previous IVF attempts (n) 0.95(0.77–1.20) 0.670   
Types of infertility
 Primary vs. Secondary 1.05(0.42–2.59) 0.920   
Basal FSH (IU/l) 1.04(0.94–1.15) 0.435   
AFC (n) 1.56(1.11–2.21) 0.011 1.62(1.11–2.37) 0.012
AMH (ng/ml) 1.44(0.52–4.00) 0.484   
aBologna criteria category
 (1 + 3) vs. (1 + 2) 4.14(0.46–37.06) 0.204   
 (2 + 3) vs. (1 + 2) 5.33(0.62–46.00) 0.128   
 (1 + 2 + 3) vs. (1 + 2) 2.80(0.32–24.24) 0.350   
  1. OR odd ratio, CI confidence interval, DHEA dehydroepiandrosterone, BMI body mass index, IVF in vitro fertilization, FSH follicle stimulation hormone, AFC antral follicle counts, AMH anti-Müllerian hormone
  2. aPoor ovarian responders (PORs) meet the Bologna criteria, having at least two of the three following features: (1) advanced maternal age (≥ 40 years) or any other risk factor for POR; (2) a previous POR (≤ 3 oocytes with a conventional stimulation protocol); (3) an abnormal ovarian reserve test. Abnormal ovarian reserve test was defined as antral follicle count (AFC) < 5 or anti-Müllerian hormone (AMH) < 1 ng/mL in this study