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Table 3 Analyses of factors affecting clinical pregnancy rate in poor ovarian responders

From: Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study

 

Univariate analysis

Multivariate analysis

OR (95% CI)

p value

Adjusted OR (95% CI)

p value

DHEA

 Yes vs. No

4.08(1.50–11.11)

0.006

4.93(1.68–14.53)

0.004

Age (years)

0.91(0.81–1.02)

0.114

0.95(0.84–1.09)

0.466

BMI (kg/m2)

1.05(0.93–1.20)

0.397

  

Infertility duration

0.90(0.79–1.03)

0.120

0.88(0.76–1.03)

0.106

Previous IVF attempts (n)

0.95(0.77–1.20)

0.670

  

Types of infertility

 Primary vs. Secondary

1.05(0.42–2.59)

0.920

  

Basal FSH (IU/l)

1.04(0.94–1.15)

0.435

  

AFC (n)

1.56(1.11–2.21)

0.011

1.62(1.11–2.37)

0.012

AMH (ng/ml)

1.44(0.52–4.00)

0.484

  

aBologna criteria category

 (1 + 3) vs. (1 + 2)

4.14(0.46–37.06)

0.204

  

 (2 + 3) vs. (1 + 2)

5.33(0.62–46.00)

0.128

  

 (1 + 2 + 3) vs. (1 + 2)

2.80(0.32–24.24)

0.350

  
  1. OR odd ratio, CI confidence interval, DHEA dehydroepiandrosterone, BMI body mass index, IVF in vitro fertilization, FSH follicle stimulation hormone, AFC antral follicle counts, AMH anti-Müllerian hormone
  2. aPoor ovarian responders (PORs) meet the Bologna criteria, having at least two of the three following features: (1) advanced maternal age (≥ 40 years) or any other risk factor for POR; (2) a previous POR (≤ 3 oocytes with a conventional stimulation protocol); (3) an abnormal ovarian reserve test. Abnormal ovarian reserve test was defined as antral follicle count (AFC) < 5 or anti-Müllerian hormone (AMH) < 1 ng/mL in this study