Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study

Table 7 Associations between candidate lipid species’ peak intensity and alleles transmitted from the other parent than those with significant fitted models

SNP	Gene	Parental Transmission	Lipid	Discovery Cohort			Validation Cohort			Meta-Analysis
SNP	Gene	Parental Transmission	Lipid	R	p-value	n	R	p-value	n	R	p-value
rs10839220	KRTAP5–6	Paternal	TG(44:1)	0.12	0.14	161	0.08	0.26	200	0.10 (−0.01, 0.20)	0.03
rs10839220	KRTAP5–6	Paternal	LysoPCP(18:0)	0.07	0.40	161	0.12	0.07	235	0.07 (−0.03, 0.17)	0.08
rs10839220	KRTAP5–6	Paternal	PE(34:0)	0.10	0.20	161	0.11	0.10	235	0.11 (0.01, 0.20)	0.02
rs10839220	KRTAP5–6	Paternal	DG(36:3)	0.05	0.53	161	0.18	8.4 × 10⁻³	213	0.12 (−0.01, 0.25)	0.03
rs4752779	FAM99B	Paternal	TG(44:1)	0.03	0.66	174	0.04	0.61	205	0.04 (−0.07, 0.14)	0.25
rs7131362	FAM99A	Paternal	TG(44:1)	0.05	0.57	159	0.01	0.86	204	0.03 (−0.08, 0.13)	0.30
rs7131362	FAM99A	Paternal	TG(48:0)	0.03	0.68	159	0.03	0.64	232	0.03 (−0.07, 0.13)	0.26
rs17073273	PLAGL1	Paternal	TG(44:1)	0.14	0.07	174	0.08	0.26	216	0.11 (0.01, 0.20)	0.02
rs17073273	PLAGL1	Paternal	TG(55:9)	0.13	0.08	174	0.03	0.66	248	0.07 (−0.03, 0.17)	0.08
rs17073273	PLAGL1	Paternal	TG(48:0)	0.19	0.01	174	0.10	0.10	248	0.14 (0.04, 0.23)	2.4 × 10⁻³
rs2268445	PLAGL1	Paternal	TG(44:1)	0.14	0.06	177	0.14	0.04	218	0.14 (0.04, 0.24)	2.7 × 10⁻³
rs7950932	H19	Maternal	TG(44:1)	0.09	0.21	183	0.09	0.22	209	0.09 (−0.01, 0.19)	0.04

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