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Table 5 Associations between maternal imprinted gene SNP genotypes and candidate lipid species’ peak intensity

From: Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study

SNP Gene Lipid Discovery Cohort Validation Cohort Meta-Analysis
R p-value n R p-value n R p-value
rs10839220 KRTAP5–6 TG(44:1) 0.157 0.04 179 0.017 0.78 225 0.08 (−0.05, 0.22) 0.12
rs10839220 KRTAP5–6 LysoPCP(18:0) 0.205 5.8 × 10−3 179 0 0.92 267 0.10 (−0.10, 0.29) 0.17
rs10839220 KRTAP5–6 PE(34:0) 0.194 9.2 × 10−3 179 0.051 0.41 267 0.12 (− 0.02, 0.25) 0.05
rs10839220 KRTAP5–6 DG(36:3) 0.224 2.6 × 10−3 179 0.062 0.34 240 0.14 (−0.02, 0.29) 0.04
rs4752779 FAM99B TG(44:1) 0.102 0.17 180 0.045 0.51 227 0.07 (−0.03, 0.17) 0.08
rs7131362 FAM99A TG(44:1) 0.222 2.9 × 10− 3 178 0.041 0.54 221 0.13 (−0.05, 0.30) 0.08
rs7131362 FAM99A TG(48:0) 0.150 0.05 178 0.030 0.64 251 0.08 (−0.03, 0.20) 0.08
rs17073273 PLAGL1 TG(44:1) 0.042 0.56 188 0.033 0.61 234 0.04 (−0.06, 0.13) 0.23
rs17073273 PLAGL1 TG(55:9) 0.125 0.09 188 0.117 0.06 267 0.12 (0.03, 0.21) 5.2 × 10−3
rs17073273 PLAGL1 TG(48:0) 0.084 0.25 188 0.057 0.35 267 0.07 (− 0.02, 0.16) 0.07
rs2268445 PLAGL1 TG(44:1) 0.046 0.54 187 0.071 0.28 231 0.06 (−0.04, 0.16) 0.11
  1. Only those lipid species that tagged components with significant fitted models in Metaboanalyst using maternally-transmitted fetal variants are shown