Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study

Table 5 Associations between maternal imprinted gene SNP genotypes and candidate lipid species’ peak intensity

SNP	Gene	Lipid	Discovery Cohort			Validation Cohort			Meta-Analysis
SNP	Gene	Lipid	R	p-value	n	R	p-value	n	R	p-value
rs10839220	KRTAP5–6	TG(44:1)	0.157	0.04	179	0.017	0.78	225	0.08 (−0.05, 0.22)	0.12
rs10839220	KRTAP5–6	LysoPCP(18:0)	0.205	5.8 × 10⁻³	179	0	0.92	267	0.10 (−0.10, 0.29)	0.17
rs10839220	KRTAP5–6	PE(34:0)	0.194	9.2 × 10⁻³	179	0.051	0.41	267	0.12 (− 0.02, 0.25)	0.05
rs10839220	KRTAP5–6	DG(36:3)	0.224	2.6 × 10⁻³	179	0.062	0.34	240	0.14 (−0.02, 0.29)	0.04
rs4752779	FAM99B	TG(44:1)	0.102	0.17	180	0.045	0.51	227	0.07 (−0.03, 0.17)	0.08
rs7131362	FAM99A	TG(44:1)	0.222	2.9 × 10^− 3	178	0.041	0.54	221	0.13 (−0.05, 0.30)	0.08
rs7131362	FAM99A	TG(48:0)	0.150	0.05	178	0.030	0.64	251	0.08 (−0.03, 0.20)	0.08
rs17073273	PLAGL1	TG(44:1)	0.042	0.56	188	0.033	0.61	234	0.04 (−0.06, 0.13)	0.23
rs17073273	PLAGL1	TG(55:9)	0.125	0.09	188	0.117	0.06	267	0.12 (0.03, 0.21)	5.2 × 10⁻³
rs17073273	PLAGL1	TG(48:0)	0.084	0.25	188	0.057	0.35	267	0.07 (− 0.02, 0.16)	0.07
rs2268445	PLAGL1	TG(44:1)	0.046	0.54	187	0.071	0.28	231	0.06 (−0.04, 0.16)	0.11

Only those lipid species that tagged components with significant fitted models in Metaboanalyst using maternally-transmitted fetal variants are shown

ISSN: 1477-7827