Fig. 7
From: Peroxiredoxin I maintains luteal function by regulating unfolded protein response
Roles of PRDX1 on progesterone production, and UPR signaling activation in CL tissue of mice. Graphical summary. Right panel; ROS reduction by PRDX1 during the luteal functional stage (48Â h after PMSG/hCG injection) in WT mice decreased activated UPR signaling in response ER stress and increased steroidogenesis enzymes expression in the CL to promote progesterone production. Left panel; Increasing ROS by PRDX1 deficiency during the luteal functional stage of Prdx1 K/O mice increased activated UPR signaling in response ER stress mediated apoptosis and decreased progesterone production related steroidogenesis enzymes expression in CL tissue and serum progesterone levels