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Fig. 7 | Reproductive Biology and Endocrinology

Fig. 7

From: Peroxiredoxin I maintains luteal function by regulating unfolded protein response

Fig. 7

Roles of PRDX1 on progesterone production, and UPR signaling activation in CL tissue of mice. Graphical summary. Right panel; ROS reduction by PRDX1 during the luteal functional stage (48 h after PMSG/hCG injection) in WT mice decreased activated UPR signaling in response ER stress and increased steroidogenesis enzymes expression in the CL to promote progesterone production. Left panel; Increasing ROS by PRDX1 deficiency during the luteal functional stage of Prdx1 K/O mice increased activated UPR signaling in response ER stress mediated apoptosis and decreased progesterone production related steroidogenesis enzymes expression in CL tissue and serum progesterone levels

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