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Table 5 Effects of Mmp9 and Pappa2 deletion on the areas of the labyrinth, junctional zone and decidua, either in absolute terms, or as a percentage of total area

From: PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction

  Term in model
  Mmp9 a Pappa2 Mmp9*Pappa2 interaction Sex of fetus
  F2,28 P F1,28 P F2,28 P F1,20 P
Absolute
 Labyrinth 0.20 0.82 0.00 0.98 1.64 0.21 0.10 0.75
 Junctional Zone 0.38 0.69 1.93 0.18 0.69 0.51 14.76 0.001b
 Decidua 3.17 0.06 7.89 0.01 2.62 0.09 2.90 0.10
Percentage of total
 Labyrinth 1.15 0.33 6.89 0.01 1.80 0.18 15.01 0.001b
 Junctional Zone 1.41 0.26 0.79 0.38 0.04 0.96 11.63 0.003b
 Decidua 4.10 0.03 6.97 0.01 3.96 0.03 0.00 0.98
  1. These analyses included multiple conceptuses per dam, and so statistics are from repeated measures analyses (with dam as a random factor), including effects of Mmp9 group, Pappa2 deletion (whether the cross included at least one functional Pappa2 allele or not), the interaction between these two factors, and fetal sex
  2. aIn these analyses, there were three Mmp9 groups: Mmp9−/− placentae from Mmp9−/− dams, Mmp9−/− placentae from Mmp9+/− dams, and Mmp9+/+ placentae from Mmp9+/+ dams
  3. bArea of the junctional zone, both absolute and as a percentage of the total area, was larger in males than females, while the area of the labyrinth as a percentage of the total was smaller in males