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Table 5 Effects of Mmp9 and Pappa2 deletion on the areas of the labyrinth, junctional zone and decidua, either in absolute terms, or as a percentage of total area

From: PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction

 

Term in model

 

Mmp9 a

Pappa2

Mmp9*Pappa2 interaction

Sex of fetus

 

F2,28

P

F1,28

P

F2,28

P

F1,20

P

Absolute

 Labyrinth

0.20

0.82

0.00

0.98

1.64

0.21

0.10

0.75

 Junctional Zone

0.38

0.69

1.93

0.18

0.69

0.51

14.76

0.001b

 Decidua

3.17

0.06

7.89

0.01

2.62

0.09

2.90

0.10

Percentage of total

 Labyrinth

1.15

0.33

6.89

0.01

1.80

0.18

15.01

0.001b

 Junctional Zone

1.41

0.26

0.79

0.38

0.04

0.96

11.63

0.003b

 Decidua

4.10

0.03

6.97

0.01

3.96

0.03

0.00

0.98

  1. These analyses included multiple conceptuses per dam, and so statistics are from repeated measures analyses (with dam as a random factor), including effects of Mmp9 group, Pappa2 deletion (whether the cross included at least one functional Pappa2 allele or not), the interaction between these two factors, and fetal sex
  2. aIn these analyses, there were three Mmp9 groups: Mmp9−/− placentae from Mmp9−/− dams, Mmp9−/− placentae from Mmp9+/− dams, and Mmp9+/+ placentae from Mmp9+/+ dams
  3. bArea of the junctional zone, both absolute and as a percentage of the total area, was larger in males than females, while the area of the labyrinth as a percentage of the total was smaller in males
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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