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Table 2 Summary of the data from the 12 features found in positive and negative ionization modes contributing to the discrimination of endometrial tissues between endometriosis patients and healthy controls

From: Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages

m/z a tR (min)b Metabolite Molecular formula Adduct Fold changec P valued Adj P valuee
HILIC mode
 131.0462 10.793 Asparagine C4H8N2O3 M-H 1.44 0.013 0.0173
 132.1019 8.833 Leucine C6H13NO2 M + H 1.68 0.002 0.0120
 137.0455 4.431 Hypoxanthine C5H4N4O M + H 1.64 0.033 0.0360
 167.0209 5.283 Uric acid C5H4N4O3 M-H 0.54 0.000 0.0053
 267.0737 4.539 Inosine C10H12N4O5 M-H 1.58 0.037 0.0370
 282.0844 6.017 Guanosine C10H13N5O5 M-H 1.55 0.023 0.0276
 283.0685 4.771 Xanthosine C10H12N4O6 M-H 2.53 0.008 0.0137
RPLC mode
 147.1125 0.696 Lysine C6H14N2O2 M + H 1.54 0.008 0.0137
 175.1186 0.703 L-Arginine C6H14N4O2 M + H 1.41 0.004 0.0137
 182.0808 1.091 L-Tyrosine C9H11NO3 M + H 1.47 0.006 0.0137
 303.2329 15.245 Omega-3 Arachidonic acid C20H32O2 M-H 1.57 0.005 0.0137
 478.2935 10.770 LPE (18:1(9Z)/0:0) C23H46NO7P M-H 1.20 0.013 0.0173
  1. am/z is the detected mass to charge ratio from LC-MS/MS runs
  2. bRetention time in minutes
  3. cThe fold change of the endometriosis group vs the control group (a higher ratio indicates a higher level of expression of a compound in the EMS group)
  4. dP value is the significance level of the difference between the two groups
  5. eP values were adjusted for false discovery rate correction at the significance level of 5%
  6. LPE lysophosphatidylethanolamine, PC phosphatidylcholine