Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages

Table 2 Summary of the data from the 12 features found in positive and negative ionization modes contributing to the discrimination of endometrial tissues between endometriosis patients and healthy controls

m/z ^a	t_R (min)^b	Metabolite	Molecular formula	Adduct	Fold change^c	P value^d	Adj P value^e
HILIC mode
131.0462	10.793	Asparagine	C₄H₈N₂O₃	M-H	1.44	0.013	0.0173
132.1019	8.833	Leucine	C₆H₁₃NO₂	M + H	1.68	0.002	0.0120
137.0455	4.431	Hypoxanthine	C₅H₄N₄O	M + H	1.64	0.033	0.0360
167.0209	5.283	Uric acid	C₅H₄N₄O₃	M-H	0.54	0.000	0.0053
267.0737	4.539	Inosine	C₁₀H₁₂N₄O₅	M-H	1.58	0.037	0.0370
282.0844	6.017	Guanosine	C₁₀H₁₃N₅O₅	M-H	1.55	0.023	0.0276
283.0685	4.771	Xanthosine	C₁₀H₁₂N₄O₆	M-H	2.53	0.008	0.0137
RPLC mode
147.1125	0.696	Lysine	C₆H₁₄N₂O₂	M + H	1.54	0.008	0.0137
175.1186	0.703	L-Arginine	C₆H₁₄N₄O₂	M + H	1.41	0.004	0.0137
182.0808	1.091	L-Tyrosine	C₉H₁₁NO₃	M + H	1.47	0.006	0.0137
303.2329	15.245	Omega-3 Arachidonic acid	C₂₀H₃₂O₂	M-H	1.57	0.005	0.0137
478.2935	10.770	LPE (18:1(9Z)/0:0)	C₂₃H₄₆NO₇P	M-H	1.20	0.013	0.0173

^am/z is the detected mass to charge ratio from LC-MS/MS runs
^bRetention time in minutes
^cThe fold change of the endometriosis group vs the control group (a higher ratio indicates a higher level of expression of a compound in the EMS group)
^dP value is the significance level of the difference between the two groups
^eP values were adjusted for false discovery rate correction at the significance level of 5%
LPE lysophosphatidylethanolamine, PC phosphatidylcholine

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