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Table 2 Serum hormone profile after 21 days of letrozole treatment

From: GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile

  Estradiol (pg/ml) Testosterone (ng/ml) Progesterone (ng/ml) Insulin(μIU/ml) HOMA-IR
Control 132.3 ± 17.37 0.315 ± 0.05 12.25 ± 0.54 7.42 ± 1.04 1.56 ± 0.14
Let-treated 139.3 ± 19.10 1.177 ± 0.07*** 9.95 ± 0.39* 15.54 ± 1.27*** 4.40 ± 0.21***
  1. All values are presented as Mean ± SEM; n = 6 per group; *P < 0.05; ***P < 0.001 as compared to control
  2. \( \mathrm{HOMA}\kern0.5em \hbox{-} \kern0.5em \mathrm{IR}\kern0.5em =\kern0.5em \frac{\left[\mathrm{Glucose}\kern0.5em \left(\mathrm{mg}/\mathrm{dl}\right)\kern0.5em \times \kern0.5em \mathrm{Insulin}\kern0.5em \left(\upmu \mathrm{IU}/\mathrm{ml}\right)\right]\kern0.5em }{405} \)