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Fig. 6 | Reproductive Biology and Endocrinology

Fig. 6

From: Modulatory effects of trophoblast-secreted CXCL12 on the migration and invasion of human first-trimester decidual epithelial cells are mediated by CXCR4 rather than CXCR7

Fig. 6

The CXCL12/CXCR4/CXCR7 axis had no effect on the viability of human first-trimester DECs in vitro. The CCK-8 assay was used to explore the effects of the CXCL12/CXCR4/CXCR7 axis on decidual epithelial cell (DEC) viability. The viability index was changed compared to the corresponding control. a The rhCXCL12 treatment had no detectable effect on the viability of human first-trimester DECs in vitro. b Effects of TCM from trophoblasts on DEC viability in vitro. CXCL12: treated with 100 ng/ml recombinant human CXCL12; anti-CXCR4, treated with 20 μg/ml CXCR4 neutralizing antibody; anti-CXCR7, treated with 10 μg/ml CXCR7 neutralizing antibody; anti-CXCL12, treated with 25 μg/ml CXCL12 neutralizing antibody; TCM: trophoblast-conditioned medium. Data are presented as average ± SEM. (n = 3)

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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