Towards a better understanding of preimplantation genetic screening for aneuploidy: insights from a virtual trial for women under the age of 40 when transferring embryos one at a time

Table 1 Hypothetical population characteristics and diagnostic accuracy measures

Virtual women (cycles) started (N)	1000
Age (y), median (range)	33 (22–39)
Cycles abandoned (n); %	15; 1.5
Oocyte retrievals (n); %	985; 98.5
Insemination by ICSI (n); %	660; 67.0
Insemination by IVF (n); %	325, 33.0
Cycles with embryos suitable for transfer or testing (n); %	870; 87.0
Embryos suitable for transfer or testing (N); median (range)	4476; 5 (1–14)
Diploid (n); %, median (range)	3073; 68.7; 3 (0–11)
Aneuploid (n); %, median (range)	1403; 31.3; 1 (0–11)
Embryos transferred, without testing, to achieve a first live birth event (n)	2204
^aPositive predictive value [TP/(TP + FP)]; %	650/683; 95.2
^bNegative predictive value [TN/(TN + FN)]; %	615/1521; 40.4
Live birth events (n)/fresh transfers (n); %	244/870; 28.0
Miscarriages (n)/fresh clinical pregnancies (n); %	27/271; 10.0

^aTest perspective without acting on the test result, the proportion of embryos transferred with an abnormal (aneuploid) test result with a correct prediction of no live birth event; ^bthe proportion with a normal (euploid) test result that correctly predict a live birth event

ISSN: 1477-7827