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Table 1 Hypothetical population characteristics and diagnostic accuracy measures

From: Towards a better understanding of preimplantation genetic screening for aneuploidy: insights from a virtual trial for women under the age of 40 when transferring embryos one at a time

Virtual women (cycles) started (N) 1000
Age (y), median (range) 33 (22–39)
Cycles abandoned (n); % 15; 1.5
Oocyte retrievals (n); % 985; 98.5
Insemination by ICSI (n); % 660; 67.0
Insemination by IVF (n); % 325, 33.0
Cycles with embryos suitable for transfer or testing (n); % 870; 87.0
Embryos suitable for transfer or testing (N); median (range) 4476; 5 (1–14)
Diploid (n); %, median (range) 3073; 68.7; 3 (0–11)
Aneuploid (n); %, median (range) 1403; 31.3; 1 (0–11)
Embryos transferred, without testing, to achieve a first live birth event (n) 2204
aPositive predictive value [TP/(TP + FP)]; % 650/683; 95.2
bNegative predictive value [TN/(TN + FN)]; % 615/1521; 40.4
Live birth events (n)/fresh transfers (n); % 244/870; 28.0
Miscarriages (n)/fresh clinical pregnancies (n); % 27/271; 10.0
  1. aTest perspective without acting on the test result, the proportion of embryos transferred with an abnormal (aneuploid) test result with a correct prediction of no live birth event; bthe proportion with a normal (euploid) test result that correctly predict a live birth event