Fig. 3

P-values for observed mosaicism, given different hypotheses r, and varying numbers of abnormal-aneuploid cells in biopsy. The curves demonstrate that, even when obtaining a mosaic TEB, with decreasing aneuploidy cell numbers in the TEB (from 6 to 1), any explanation with increasing r from r < 0.4 to r < 0.99 could be a reasonable explanation of the observed data since it leads to observing mosaicism in >5% of cases. The threshold at which r crosses the significance level increases with decreasing aneuploidy. This means that a given r is more likely to explain the obtained biopsy result the lower the measured aneuploidy is. For example, if one (or more) cells are aneuploid, the threshold will be approximately r = 0.99, meaning that even a hypothesis of r = 0.99, basically an entirely euploid embryo, is compatible with the data. On the other hand, if three (or more) cells are aneuploid, a hypothesis with an r as high 0.99 is too unlikely to give the observed data, and only an r < 0.85 hypothesis is compatible with this biopsy outcome