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Table 1 List of the common proteins identified in exosomes of ICAR cultured at 1 % O2 and at 8 % O2

From: Characterization of exosomal release in bovine endometrial intercaruncular stromal cells

A. List of 113 common proteins identified in exosomes of ICAR cultured at 1 % O2 and at 8 % O2
Protein ID Name Gene Name Biological Process (Total # Gene 69; Total #Function 146) Molecular function (Total # Gene 69; Total #Function 81)
 A1L523_BOVIN Copine II (Fragment) CPNE2   
 A3KN51_BOVIN TSG101 protein TSG101 Metabolic process Catalytic activity
 A5D7L1_BOVIN CLEC11A protein CLEC11A Cellular process/Developmental process Binding/Structural molecule activity
 A5D9D2_BOVIN Complement component 4 binding protein, alpha chain C4BPA   
 A5PJ69_BOVIN SERPINA10 protein SERPINA10 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 A5PJE3_BOVIN Fibrinogen alpha chain FGA   
 A5PK77_BOVIN SERPINA11 protein SERPINA11 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 A6QLB7_BOVIN Adenylyl cyclase-associated protein CAP1   
 A6QLL8_BOVIN Fructose-bisphosphate aldolase ALDOA   
 A6QNZ7_BOVIN Keratin 10 (Epidermolytic hyperkeratosis; keratosis palmaris et plantaris) KRT10   
 A6QPP2_BOVIN SERPIND1 protein SERPIND1 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 A6QPR1_BOVIN PCYOX1 protein PCYOX1   
 LG3BP_BOVIN Galectin-3-binding protein LGALS3BP Apoptotic process/Biological adhesion/Biological regulation/Cellular process/Developmental process/Immune system process/localization/Metabolic process Catalytic activity/Receptor activity
 A7MB82_BOVIN C1QTNF3 protein C1QTNF3   
 A7YWB6_BOVIN LOC539596 protein LOC539596   
 B0JYM4_BOVIN Tetraspanin CD63   
 B0JYN6_BOVIN Alpha-2-HS-glycoprotein AHSG   
 B0JYQ0_BOVIN ALB protein ALB   
 B5B3R8_BOVIN Alpha S1 casein CSN1S1   
 E1BDG5_BOVIN Protein Wnt WNT5A Biological regulation/Cellular process/Developmental process/Multicellular organismal process/Response to stimulus Binding
 CBG_BOVIN Corticosteroid-binding globulin SERPINA6 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 F1MAV0_BOVIN Fibrinogen beta chain FGB   
 F1MB08_BOVIN Alpha-enolase ENO1   
 F1MC11_BOVIN Keratin, type I cytoskeletal 14 KRT14   
 F1MM32_BOVIN Sulfhydryl oxidase QSOX1   Catalytic activity
 F1MMK9_BOVIN Protein AMBP AMBP   
 F1MMP5_BOVIN Inter-alpha-trypsin inhibitor heavy chain H1 ITIH1   
 ITA3_BOVIN Integrin alpha-3 ITGA3   
 F1MNW4_BOVIN Inter-alpha-trypsin inhibitor heavy chain H2 ITIH2   
 F1MSZ6_BOVIN Antithrombin-III SERPINC1   
 F1MTV5_BOVIN Amino acid transporter SLC1A5   
 F1MW44_BOVIN Coagulation factor XIII A chain F13A1   
 F1MXJ5_BOVIN IST1 homolog IST1   
 F1MXX6_BOVIN Lactadherin MFGE8   
 F1MY85_BOVIN Complement C5a anaphylatoxin C5   
 F1N045_BOVIN Complement component C7 C7   
 HTRA1_BOVIN Serine protease HTRA1 HTRA1 Cellular process/Metabolic process Catalytic activity
 F1N1I6_BOVIN Gelsolin GSN   
 F6QVC9_BOVIN Annexin ANXA5   
 G3X6N3_BOVIN Serotransferrin TF   
 G5E5A9_BOVIN Fibronectin FN1   
 G5E5V0_BOVIN Carboxypeptidase N catalytic chain CPN1   
 G8JKX6_BOVIN Tetraspanin (Fragment) CD9   
 I7CT57_BOVIN Vitamin D binding protein    
 M0QVZ6_BOVIN Keratin, type II cytoskeletal 5 KRT5   
 THRB_BOVIN Prothrombin F2 Immune system process/Metabolic process/Response to stimulus Catalytic activity
 PROC_BOVIN Vitamin K-dependent protein C (Fragment) PROC Response to stimulus Binding
 KNG2_BOVIN Kininogen-2 KNG2   
 THYG_BOVIN Thyroglobulin TG Metabolic process Catalytic activity
 HBA_BOVIN Hemoglobin subunit alpha HBA localization/Multicellular organismal process  
 HBBF_BOVIN Hemoglobin fetal subunit beta   localization/Multicellular organismal process  
 ALBU_BOVIN Serum albumin ALB localization  
 ANXA2_BOVIN Annexin A2 ANXA2 Developmental process/Metabolic process  
 ASSY_BOVIN Argininosuccinate synthase ASS1 Cellular process/Metabolic process Catalytic activity
 APOH_BOVIN Beta-2-glycoprotein 1 APOH Cellular process/Immune system process/localization/Metabolic process/Response to stimulus Catalytic activity/Receptor activity/Transporter activity
 CLUS_BOVIN Clusterin CLU   
 HSP7C_BOVIN Heat shock cognate 71 kDa protein HSPA8 Cellular component organization or biogenesis/Immune system process/Metabolic process/Response to stimulus  
 ANXA7_BOVIN Annexin A7 ANXA7 Metabolic process  
 ANX11_BOVIN Annexin A11 ANXA11 Metabolic process  
 A2AP_BOVIN Alpha-2-antiplasmin SERPINF2 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 A1AT_BOVIN Alpha-1-antiproteinase SERPINA1 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 GDIB_BOVIN Rab GDP dissociation inhibitor beta GDI2 Biological regulation/Cellular process/localization/Metabolic process/Multicellular organismal process Binding/Catalytic activity/Enzyme regulator activity
 F12AI_BOVIN Factor XIIa inhibitor    
 ITB1_BOVIN Integrin beta-1 ITGB1 Biological adhesion/Cellular process/Response to stimulus Receptor activity
 ITIH3_BOVIN Inter-alpha-trypsin inhibitor heavy chain H3 ITIH3 Biological regulation/Metabolic process Binding/Catalytic activity/Enzyme regulator activity
 ACTB_BOVIN Actin, cytoplasmic 1 ACTB Cellular component organization or biogenesis/Cellular process/Developmental process/localization Structural molecule activity
 ANXA6_BOVIN Annexin A6 ANXA6 Metabolic process  
 CFAB_BOVIN Complement factor B CFB Biological adhesion/Cellular process/Immune system process/localization/Metabolic process/Response to stimulus Catalytic activity/Receptor activity/Transporter activity
 TBA1B_BOVIN Tubulin alpha-1B chain   Cellular process/Developmental process/localization Structural molecule activity
 LUM_BOVIN Lumican LUM Biological adhesion/Biological regulation/Cellular process/Developmental process/Immune system process/Metabolic process/Multicellular organismal process Receptor activity
 UPAR_BOVIN Urokinase plasminogen activator surface receptor PLAUR   
 5NTD_BOVIN 5’-nucleotidase NT5E Metabolic process Catalytic activity
 PGM1_BOVIN Phosphoglucomutase-1 PGM1 Cellular process/Metabolic process Catalytic activity
 Q09TE3_BOVIN Insulin-like growth factor binding protein acid labile subunit    
 Q17R18_BOVIN Adenosine kinase ADK   
 FA5_BOVIN Coagulation factor V F5 Biological adhesion/Biological regulation/Cellular process/Developmental process/Immune system process/localization/Metabolic process/Multicellular organismal process/Response to stimulus Binding/Catalytic activity/Enzyme regulator activity/Receptor activity/Transporter activity
 Q2KIF2_BOVIN Leucine-rich alpha-2-glycoprotein 1 LRG1 Cellular process/Multicellular organismal process Receptor activity
 CBPB2_BOVIN Carboxypeptidase B2 CPB2 Metabolic process Catalytic activity
 Q2KJ47_BOVIN EH-domain containing 2 EHD2 Biological regulation/Cellular process/localization/Metabolic process/Multicellular organismal process Binding/Catalytic activity/Enzyme regulator activity
 TBB5_BOVIN Tubulin beta-5 chain TUBB5 Cellular process/Developmental process/localization Structural molecule activity
 A1BG_BOVIN Alpha-1B-glycoprotein A1BG Cellular process/Immune system process/Response to stimulus Binding/Receptor activity
 HPT_BOVIN Haptoglobin HP Biological regulation/Immune system process/localization/Metabolic process/Multicellular organismal process/Reproduction/Response to stimulus Binding/Catalytic activity/Enzyme regulator activity/Receptor activity
 CO3_BOVIN Complement C3 C3 Biological regulation/Cellular process/Metabolic process/Response to stimulus Binding/Catalytic activity/Enzyme regulator activity
 Q3MHH8_BOVIN Alpha-amylase AMY2A   
 SAHH_BOVIN Adenosylhomocysteinase AHCY Cellular process/Metabolic process Catalytic activity
 CO9_BOVIN Complement component C9 C9 Cellular process/localization/Metabolic process/Response to stimulus Catalytic activity/Receptor activity/Transporter activity
 Q3MHW2_BOVIN F10 protein (Fragment) F10   
 Q3MHZ0_BOVIN FLOT1 protein (Fragment) FLOT1   
 Q3SYR0_BOVIN Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 7 SERPINA7   
 FETA_BOVIN Alpha-fetoprotein AFP Developmental process/localization  
 Q3SZH5_BOVIN Angiotensinogen AGT   
 HEMO_BOVIN Hemopexin HPX localization  
 Q3SZZ9_BOVIN FGG protein FGG   
 PGK1_BOVIN Phosphoglycerate kinase 1 PGK1 Metabolic process Catalytic activity
 Q3T101_BOVIN IGL@ protein IGL@   
 G6PI_BOVIN Glucose-6-phosphate isomerase GPI Metabolic process Catalytic activity
 Q3ZBX0_BOVIN Basigin BSG   
 Q3ZC87_BOVIN Pyruvate kinase (Fragment) PKM2   
 Q3ZCI4_BOVIN 6-phosphogluconate dehydrogenase, decarboxylating PGD Metabolic process Catalytic activity
 FETUB_BOVIN Fetuin-B FETUB   
 EHD1_BOVIN EH domain-containing protein 1 EHD1 Biological regulation/Cellular process/localization/Metabolic process/Multicellular organismal process Binding/Catalytic activity/Enzyme regulator activity
 HPPD_BOVIN 4-hydroxyphenylpyruvate dioxygenase HPD Metabolic process Catalytic activity
 Q5EA67_BOVIN Inter-alpha (Globulin) inhibitor H4 (Plasma Kallikrein-sensitive glycoprotein) ITIH4   
 Q5GN72_BOVIN Alpha-1-acid glycoprotein agp   
 BHMT1_BOVIN Betaine--homocysteine S-methyltransferase 1 BHMT Cellular process/Metabolic process Catalytic activity
 Q5J801_BOVIN Endopin 2B    
 Q6T182_BOVIN Sex hormone-binding globulin (Fragment) SHBG   
 A2MG_BOVIN Alpha-2-macroglobulin A2M Biological regulation/Cellular process/Immune system process/Metabolic process/Response to stimulus Binding/Catalytic activity/Enzyme regulator activity
 PEDF_BOVIN Pigment epithelium-derived factor SERPINF1 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 CHIA_BOVIN Acidic mammalian chitinase CHIA Immune system process/Metabolic process/Response to stimulus Binding/Catalytic activity
 IPSP_BOVIN Plasma serine protease inhibitor SERPINA5 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 SPA31_BOVIN Serpin A3-1 SERPINA3-1 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 V6F9A2_BOVIN Apolipoprotein A-I preproprotein APOA1   
B. List of 128 unique proteins identified in exosomes of ICAR cultured at 1 % O2
Protein ID Name Gene Name Biological Process (Total # Gene 22; Total #Function 49) Molecular function (Total # Gene 22; Total #Function 28)
 G3X6T9_BOVIN Flotillin-2 (Fragment) FLOT2   
 TSP1_BOVIN Thrombospondin-1 THBS1   
 F1N2L9_BOVIN 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1   
 E1B9F6_BOVIN Elongation factor 1-alpha EEF1A1   
 APOE_BOVIN Apolipoprotein E APOE Apoptotic process/Biological regulation/Cellular component organization or biogenesis/Cellular process/Developmental process/Growth/localization/Metabolic process/Multicellular organismal process/Response to stimulus Binding/Catalytic activity/ Enzyme regulator activity/Transporter activity
 G1K1R6_BOVIN Galactokinase GALK1   
 G3P_BOVIN Glyceraldehyde-3-phosphate dehydrogenase GAPDH Metabolic process Catalytic activity
 Q0P5B0_BOVIN Arrestin domain containing 1 ARRDC1   
 RL40_BOVIN Ubiquitin-60S ribosomal protein L40 UBA52 Metabolic process Binding/Structural molecule activity
 A5D9B6_BOVIN Syntenin SDCBP   
 Q8HZY1_BOVIN Serine protease inhibitor clade E member 2 SERPINE2   
 Q5E962_BOVIN Aldo-keto reductase family 1, member B1 AKR1B1   
 A7MBH9_BOVIN GNAI2 protein GNAI2 Biological regulation/Cellular process/Metabolic process/Response to stimulus Binding/Catalytic activity
 GBB2_BOVIN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 GNB2 Cellular process/Metabolic process/Multicellular organismal process Binding/Catalytic activity
 I6YIV1_BOVIN Annexin    
 F16P1_BOVIN Fructose-1,6-bisphosphatase 1 FBP1 Metabolic process  
 F1N3Q7_BOVIN Apolipoprotein A-IV APOA4   
 AK1A1_BOVIN Alcohol dehydrogenase [NADP(+)] AKR1A1 localization/Metabolic process Catalytic activity/Transporter activity
 A5D784_BOVIN CPNE8 protein CPNE8 localization  
 HS90A_BOVIN Heat shock protein HSP 90-alpha HSP90AA1 Immune system process/Metabolic process/Response to stimulus  
 Q1JPA2_BOVIN Eukaryotic translation elongation factor 1 gamma (Fragment) EEF1G   
 SERA_BOVIN D-3-phosphoglycerate dehydrogenase PHGDH Metabolic process Catalytic activity
 Q3T085_BOVIN OGN protein OGN   
 A8DBT6_BOVIN Monocyte differentiation antigen CD14 CD14   
 A5PK73_BOVIN Fructose-bisphosphate aldolase ALDOB   
 G5E5U7_BOVIN S-adenosylmethionine synthase MAT1A   
 F1N2W0_BOVIN Prostaglandin reductase 1 PTGR1   
 IF4A1_BOVIN Eukaryotic initiation factor 4A-I EIF4A1 Biological regulation/Metabolic process Binding/Catalytic activity/Translation regulator activity
 Q05B55_BOVIN IGK protein IGK   
 F1N1D4_BOVIN Protein tweety homolog TTYH3 localization Transporter activity
 A4FV94_BOVIN KRT6A protein KRT6A   
 RGN_BOVIN Regucalcin RGN Cellular process/localization/Metabolic process Binding/Catalytic activity
 1433E_BOVIN 14-3-3 protein epsilon YWHAE Cellular process  
 Q2HJB6_BOVIN Procollagen C-endopeptidase enhancer PCOLCE Biological adhesion/Biological regulation/Cellular process/Developmental process/Immune system process/localization/Metabolic process/Multicellular organismal process/Response to stimulus Binding/Catalytic activity/Enzyme regulator activity/Receptor activity/Transporter activity
 B8YB76_BOVIN Homogentisate 1,2-dioxygenase HGD   
 DHSO_BOVIN Sorbitol dehydrogenase SORD Metabolic process Catalytic activity
 HS71A_BOVIN Heat shock 70 kDa protein 1A HSPA1A Cellular component organization or biogenesis/Immune system process/Metabolic process/Response to stimulus  
 Q3ZBQ9_BOVIN APOM protein APOM   
 PYGL_BOVIN Glycogen phosphorylase, liver form PYGL Metabolic process Catalytic activity
 A6QP30_BOVIN CPN2 protein CPN2 Cellular process/Multicellular organismal process Receptor activity
 ARF3_BOVIN ADP-ribosylation factor 3 ARF3 Cellular process/localization/Metabolic process Binding/Catalytic activity
 G3MYH4_BOVIN Tetraspanin (Fragment) CD81   
 ACTC_BOVIN Actin, alpha cardiac muscle 1 ACTC1 Cellular component organization or biogenesis/Cellular process/Developmental process/localization Structural molecule activity
 GALM_BOVIN Aldose 1-epimerase GALM Metabolic process Catalytic activity
 TSN6_BOVIN Tetraspanin-6 TSPAN6 Biological adhesion/Cellular process/Immune system process/Multicellular organismal process/Reproduction/Response to stimulus Binding/Receptor activity
 Q3ZC83_BOVIN Solute carrier family 29 (Nucleoside transporters), member 1 SLC29A1 localization/Metabolic process Transporter activity
 B4GA1_BOVIN Beta-1,4-glucuronyltransferase 1 B4GAT1 Metabolic process Catalytic activity
 ADA10_BOVIN Disintegrin and metalloproteinase domain-containing protein 10 ADAM10 Apoptotic process/Developmental process/Reproduction  
 A6QR28_BOVIN Phosphoserine aminotransferase PSAT1 Metabolic process Catalytic activity
 Q1JPB6_BOVIN Acetyl-Coenzyme A acetyltransferase 2 ACAT2   
 DDBX_BOVIN Dihydrodiol dehydrogenase 3   localization/Metabolic process Catalytic activity/Transporter activity
 A2VE11_BOVIN IGSF8 protein IGSF8   
 F1MS32_BOVIN Apolipoprotein D APOD   
 A6QP64_BOVIN VPS37B protein (Fragment) VPS37B   
 Q2KIW4_BOVIN Lecithin-cholesterol acyltransferase LCAT Metabolic process Catalytic activity
 GBB1_BOVIN Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 Cellular process/Metabolic process Binding/Catalytic activity
 GNA11_BOVIN Guanine nucleotide-binding protein subunit alpha-11 GNA11 Biological regulation/Cellular process/Metabolic process/Response to stimulus Catalytic activity
 Q17QK4_BOVIN Epoxide hydrolase 2, cytoplasmic EPHX2   
 K2C7_BOVIN Keratin, type II cytoskeletal 7 KRT7 Cellular component organization or biogenesis/Cellular process/Developmental process Structural molecule activity
 CLIC1_BOVIN Chloride intracellular channel protein 1 CLIC1 Biological regulation/Cellular process/Metabolic process/Response to stimulus Binding/Catalytic activity/Structural molecule activity/Translation regulator activity
 Q08DW4_BOVIN Mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) MASP1   
 B4GT1_BOVIN Beta-1,4-galactosyltransferase 1 B4GALT1   
 A5D7E6_BOVIN Tetraspanin CD82 Cellular process/Response to stimulus Binding/Receptor activity
 A5D973_BOVIN Alpha isoform of regulatory subunit A, protein phosphatase 2 PPP2R1A   
 E1B726_BOVIN Plasminogen PLG   
 G5E6I9_BOVIN Histone H2B LOC101904777 Cellular component organization or biogenesis/Cellular process/Metabolic process Binding
 ADIPO_BOVIN Adiponectin ADIPOQ   
 F1MBC5_BOVIN Coagulation factor IX F9   
 A2VDL2_BOVIN Solute carrier family 2 (Facilitated glucose transporter), member 3 SLC2A3   
 VPS4B_BOVIN Vacuolar protein sorting-associated protein 4B VPS4B   
 G3X8B1_BOVIN Peptidyl-prolyl cis-trans isomerase LOC613401   
 K4JB97_BOVIN Alpha-2-macroglobulin variant 4 A2M   
 ACTG_BOVIN Actin, cytoplasmic 2 ACTG1 Cellular component organization or biogenesis/Cellular process/localization Structural molecule activity
 Q1JPG7_BOVIN Pyruvate kinase PKLR   
 GTR1_BOVIN Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1   
 F1N342_BOVIN Protein tweety homolog TTYH2 localization Transporter activity
 ADHX_BOVIN Alcohol dehydrogenase class-3 ADH5 Metabolic process Catalytic activity
 URP2_BOVIN Fermitin family homolog 3 FERMT3   
 E1B7N2_BOVIN Histone H4 HIST1H4I Cellular component organization or biogenesis/Cellular process/Metabolic process Binding
 EF2_BOVIN Elongation factor 2 EEF2 Biological regulation/Metabolic process Binding/Translation regulator activity
 KLKB1_BOVIN Plasma kallikrein KLKB1 Biological regulation/localization/Metabolic process/Response to stimulus Binding/Catalytic activity/Enzyme regulator activity/Receptor activity
 ESTD_BOVIN S-formylglutathione hydrolase ESD Metabolic process Catalytic activity
 SEPR_BOVIN Prolyl endopeptidase FAP FAP Cellular process/Immune system process/localization/Metabolic process/Multicellular organismal process / Response to stimulus Binding/Catalytic activity
 Q5EA54_BOVIN Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2 SLC3A2   
 Q1JPD9_BOVIN G protein-coupled receptor, family C, group 5, member B GPRC5B Cellular process Receptor activity
 F1MS05_BOVIN Aconitate hydratase ACO1   
 F1MJ12_BOVIN Complement C1s subcomponent C1S   
 CNDP2_BOVIN Cytosolic non-specific dipeptidase CNDP2 Metabolic process Catalytic activity
 Q2TBQ1_BOVIN Coagulation factor XIII, B polypeptide F13B Biological adhesion/Cellular process/Immune system process/localization/Metabolic process/Response to stimulus Catalytic activity/Receptor activity/Transporter activity
 Q1JP72_BOVIN Colony stimulating factor 1 receptor CSF1R   
 Q0VD03_BOVIN CD44 antigen CD44   
 G3X6Y4_BOVIN Osteomodulin OMD   
 GAMT_BOVIN Guanidinoacetate N-methyltransferase GAMT   
 VWA1_BOVIN von Willebrand factor A domain-containing protein 1 VWA1   
 SERC3_BOVIN Serine incorporator 3 SERINC3   
 Q862H8_BOVIN Similar to 40S ribosomal protein SA (P40) (Fragment)    
 A8E4P3_BOVIN STOM protein STOM   
 F1MHP6_BOVIN Adenylosuccinate lyase ADSL   
 E1BMG9_BOVIN 10-formyltetrahydrofolate dehydrogenase ALDH1L1 Metabolic process Catalytic activity
 Q705V4_BOVIN Kappa-casein (Fragment) csn3   
 G3X6Q8_BOVIN Pentraxin-related protein PTX3 PTX3   
 K7QEL2_BOVIN MHC class I antigen BoLA   
 TCPQ_BOVIN T-complex protein 1 subunit theta CCT8 Cellular component organization or biogenesis / Metabolic process  
 F1N6Z0_BOVIN 26S proteasome non-ATPase regulatory subunit 5 PSMD5   
 ARLY_BOVIN Argininosuccinate lyase ASL Metabolic process Catalytic activity
 E1BNG2_BOVIN alpha-1,2-Mannosidase MAN1A1 Metabolic process  
 F1MU79_BOVIN Peptidyl-prolyl cis-trans isomerase FKBP4 FKBP4   
 DPYL2_BOVIN Dihydropyrimidinase-related protein 2 DPYSL2 Metabolic process Catalytic activity
 PRS23_BOVIN Serine protease 23 PRSS23   
 B0JYN1_BOVIN Cathepsin L2 CTSL2   
 A4FV99_BOVIN FCNB protein FCNB   
 A7YW37_BOVIN CD58 protein (Fragment) CD58 Immune system process/Response to stimulus Binding
 F1MTP5_BOVIN WD repeat-containing protein 1 WDR1   
 A7E3D0_BOVIN CCDC45 protein (Fragment) CCDC45   
 Q0VCK1_BOVIN Myeloid-associated differentiation marker MYADM   
 A1L570_BOVIN Ephrin-B1 EFNB1 Biological regulation/Cellular component organization or biogenesis/Cellular process/Developmental process/locomotion/Multicellular organismal process/Response to stimulus Binding
 F1N049_BOVIN Actin-related protein 3 (Fragment) ACTR3   
 PAI1_BOVIN Plasminogen activator inhibitor 1 SERPINE1 Biological regulation/Metabolic process Catalytic activity/Enzyme regulator activity
 Q3ZC30_BOVIN Sulfotransferase SULT1E1   
 COL11_BOVIN Collectin-11 COLEC11 Biological regulation/Immune system process/Multicellular organismal process  
 MPZL1_BOVIN Myelin protein zero-like protein 1 MPZL1 Cellular process/localization Transporter activity
 G5E595_BOVIN Lys-63-specific deubiquitinase BRCC36 BRCC3   
 O18977_BOVIN Tenascin-X TN-X   
 A6H7D3_BOVIN KRT18 protein (Fragment) KRT18   
 J9ZXG5_BOVIN Integrin alpha V subunit    
 B0JYN3_BOVIN L-lactate dehydrogenase LDHB   
 MB211_BOVIN Protein mab-21-like 1 MAB21L1   
 E1B7R4_BOVIN Eukaryotic translation initiation factor 3 subunit A EIF3A Biological regulation/Metabolic process Binding/Translation regulator activity
C. List of 46 unique proteins identified in exosomes of ICAR cultured at 8 % O2
Protein ID Name Gene Name Biological Process (Total # Gene 22; Total #Function 49) Molecular function (Total # Gene 22; Total #Function 28)
 F1MMD7_BOVIN Inter-alpha-trypsin inhibitor heavy chain H4 ITIH4   
 F1N3A1_BOVIN Thrombospondin-1 THBS1   
 PLMN_BOVIN Plasminogen PLG Biological regulation/localization/Metabolic process/Response to stimulus Binding/Catalytic activity/Enzyme regulator activity/Receptor activity
 F1MYN5_BOVIN Fibulin-1 FBLN1 Cellular process/Developmental process Binding
 F1MNV5_BOVIN Kininogen-1 KNG1   
 EF1A1_BOVIN Elongation factor 1-alpha 1 EEF1A1 Biological regulation/Metabolic process Binding/Catalytic activity/Translation regulator activity
 ITAV_BOVIN Integrin alpha-V ITGAV Biological adhesion  
 F1MK44_BOVIN Integrin alpha-5 ITGA5   
 TTHY_BOVIN Transthyretin TTR localization Transporter activity
 F1MC45_BOVIN Complement factor H (Fragment) CFH   
 J9QD97_BOVIN Periostin variant 9    
 ACTS_BOVIN Actin, alpha skeletal muscle ACTA1 Cellular component organization or biogenesis/Cellular process/Developmental process/localization Structural molecule activity
 E1B9K1_BOVIN Polyubiquitin-C UBC   
 A7YWR0_BOVIN Apolipoprotein E APOE   
 FA9_BOVIN Coagulation factor IX F9 Apoptotic process/Biological regulation/Developmental process/Immune system process/ localization/Metabolic process/Multicellular organismal process/Response to stimulus Binding/Catalytic activity/Enzyme regulator activity/Receptor activity
 COMP_BOVIN Cartilage oligomeric matrix protein COMP   
 K2C80_BOVIN Keratin, type II cytoskeletal 80 KRT80 Cellular component organization or biogenesis/Cellular process/Developmental process Structural molecule activity
 TRFE_BOVIN Serotransferrin TF localization/Metabolic process Catalytic activity
 K4JDR8_BOVIN Alpha-2-macroglobulin variant 5 A2M   
 Q32P72_BOVIN CP protein (Fragment) CP   
 J9ZW47_BOVIN Integrin beta    
 F1MM86_BOVIN Complement component C6 C6   
 E1BI02_BOVIN Fibromodulin FMOD   
 VNN1_BOVIN Pantetheinase VNN1 Biological adhesion/Cellular process/Metabolic process Catalytic activity
 G3X807_BOVIN Histone H4 (Fragment)   Cellular component organization or biogenesis/Cellular process/Metabolic process Binding
 MOT1_BOVIN Monocarboxylate transporter 1 SLC16A1 Cellular process/localization Transporter activity
 TF_BOVIN Tissue factor F3 Biological regulation/Cellular process/Response to stimulus Binding/Receptor activity
 HS71L_BOVIN Heat shock 70 kDa protein 1-like HSPA1L Metabolic process/Response to stimulus  
 Q3ZCA7_BOVIN Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 GNAI3 Biological regulation/Cellular process/Metabolic process/Response to stimulus Binding/Catalytic activity
 IDHC_BOVIN Isocitrate dehydrogenase [NADP] cytoplasmic IDH1   
 Q1PBC8_BOVIN CD14 (Fragment)    
 F1MJJ8_BOVIN Radixin (Fragment) RDX   
 IF4A2_BOVIN Eukaryotic initiation factor 4A-II EIF4A2 Biological regulation/Metabolic process Binding/Catalytic activity/Translation regulator activity
 C1QB_BOVIN Complement C1q subcomponent subunit B C1QB   
 A6QPD4_BOVIN LOC790886 protein LOC790886   
 CTL2_BOVIN Choline transporter-like protein 2 SLC44A2 localization Transporter activity
 HPCL1_BOVIN Hippocalcin-like protein 1 HPCAL1 Cellular process/Multicellularorganismal process  
 Q24K07_BOVIN Vacuolar protein sorting 11 homolog (S. cerevisiae) VPS11   
 Q5H9M6_BOVIN Dynein heavy chain (Fragment) Bv2   
 Q864S1_BOVIN Cathepsin C (Fragment)    
 Q4ZJS0_BOVIN MHC class I antigen (Fragment) BoLA-N   
 Q58CZ4_BOVIN Flotillin 2 FLOT2   
 MBL2_BOVIN Mannose-binding protein C MBL   Binding
 TM214_BOVIN Transmembrane protein 214 TMEM214   
 Q8MIR1_BOVIN Nicotinic acetylcholine receptor beta 2 subunit (Fragment) CHRNB2   
 Q5E9W1_BOVIN CDC45-like CDC45L   
  1. Mass spectrometric (with a set FDR of 5 %) identification of proteins was present in exosomes generated by ICAR cultured at 1 % O2 and at 8 % O2. Data were subjected to ontology and pathway analysis using PANTHER and gene ontology algorithms and classified based on biological process and molecular function