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Table 1 Effects of vitrifying before and after IVM on oocyte viability, IVM and early embryo development

From: Osmotic-shock produced by vitrification solutions improves immature human oocytes in vitro maturation

  G1 G2 G3 P -value
IVMR 63.4 % (26/41) 83.7 % (↑) (36/43) 56.6 % (30/53) 0.016
AR 73.1 % (19/26) 80.6 % (29/36) 96.7 % (↑) (29/30) 0.047
DRC 68.4 % (13/19) 82.8 % (24/29) 69.0 % (20/29) 0.397
DRCM 15.8 % (3/19) 20.7 % (6/29) 0.0 % (↓) (0/29) 0.040
DRB 0.0 % (0/19) 3.5 % (1/29) 0.0 % (0/29) 0.432
  1. Group 1 (Control group): 41 GV-oocytes in vitro matured until MII; Group 2 (oocytes vitrified at GV stage): 43 oocytes vitrified at GV stage warmed and in vitro matured until MII and Group 3 (oocytes vitrified at MII stage): 53 GV-oocytes in vitro matured until MII and then vitrified. In vitro oocyte maturation rate (IVMR), oocyte activation rate (AR), development rate to 2-cells embryo at day 2 (DRC), development rate to morula at day 4 (DRCM), development rate to blastocyst at day 5 (DRB). (↑), (↓): The arrow indicates the group that is statistically different from the other two in the ratio value. The direction of the arrow indicates the direction of change in the value of the ratio