The association of serum estradiol level with outcomes of clomiphene citrate/human menopausal gonadotropin ovarian stimulation for in vitro fertilization and embryo transfer

Table 3 Serum E₂ levels and frozen embryo transfer (FET) outcomes

	Group A:	Group B:	Group C:	P	P _adj ^d
	E₂ ≤ 30 pg/ml	30 < E₂ ≤ 50 pg/ml	E₂ > 50 pg/ml	P	P _adj ^d
Number of transfer cycles	241	350	225
Number of transferred embryos^a	2 (2, 3)	2 (2, 3)	2 (2, 3)	0.574	0.510
Number of transferred good quality embryos^a	2 (1, 2)	2 (1, 2)	2 (1, 2)	0.366	0.431
Endometrial thickness, mm^a	10 (9, 11)	10 (9, 11)	10 (9, 11)	0.543	0.383
Successful embryo implantation^b,c	115 (22.0)	195 (25.1)	93 (18.6)*	0.023	-
Ongoing clinical pregnancy^b	94 (29.9)	154 (34.1)	78 (25.1)*	0.027	0.552 (Group A)
Ongoing clinical pregnancy^b	94 (29.9)	154 (34.1)	78 (25.1)*	0.027	0.036 (Group B)
Abortion^b	9 (2.8)	18 (4)	16 (5.1)	0.349	0.198 (Group A)
Abortion^b	9 (2.8)	18 (4)	16 (5.1)	0.349	0.520 (Group B)
Ectopic pregnancy^b	3 (0.9)	6 (1.3)	1 (0.3)	0.357	0.410 (Group A)
Ectopic pregnancy^b	3 (0.9)	6 (1.3)	1 (0.3)	0.357	0.213 (Group B)

Dash indicates statistical analysis with adjustment was unavailable as there were second-hand data used for analysis
Continuous data are presented as median (interquartile range) and examined by Kruskal-Wallis^a test. Categorical data are expressed as n (%) and tested by chi-square test^b
^cEmbryo implantation rate was calculated as: total number of embryos which are implanted/total number of embryos transferred
^dRank transformation was applied to continuous data, and tested by analysis of covariance adjusting for age, body mass index (BMI), and baseline E₂ level. Probabilities of ongoing clinical pregnancy, abortion, and ectopic pregnancy were examined by logistic regression adjusting for age, BMI, and baseline E₂ level
*Indicates significant difference between group B and group C, P < 0.017; chi-square test with Bonferroni correction

ISSN: 1477-7827