Skip to main content

Table 3 Serum E2 levels and frozen embryo transfer (FET) outcomes

From: The association of serum estradiol level with outcomes of clomiphene citrate/human menopausal gonadotropin ovarian stimulation for in vitro fertilization and embryo transfer

  Group A: Group B: Group C: P P adj d
E2 ≤ 30 pg/ml 30 < E2 ≤ 50 pg/ml E2 > 50 pg/ml
Number of transfer cycles 241 350 225   
Number of transferred embryosa 2 (2, 3) 2 (2, 3) 2 (2, 3) 0.574 0.510
Number of transferred good quality embryosa 2 (1, 2) 2 (1, 2) 2 (1, 2) 0.366 0.431
Endometrial thickness, mma 10 (9, 11) 10 (9, 11) 10 (9, 11) 0.543 0.383
Successful embryo implantationb,c 115 (22.0) 195 (25.1) 93 (18.6)* 0.023 -
Ongoing clinical pregnancyb 94 (29.9) 154 (34.1) 78 (25.1)* 0.027 0.552 (Group A)
0.036 (Group B)
Abortionb 9 (2.8) 18 (4) 16 (5.1) 0.349 0.198 (Group A)
0.520 (Group B)
Ectopic pregnancyb 3 (0.9) 6 (1.3) 1 (0.3) 0.357 0.410 (Group A)
0.213 (Group B)
  1. Dash indicates statistical analysis with adjustment was unavailable as there were second-hand data used for analysis
  2. Continuous data are presented as median (interquartile range) and examined by Kruskal-Wallisa test. Categorical data are expressed as n (%) and tested by chi-square testb
  3. cEmbryo implantation rate was calculated as: total number of embryos which are implanted/total number of embryos transferred
  4. dRank transformation was applied to continuous data, and tested by analysis of covariance adjusting for age, body mass index (BMI), and baseline E2 level. Probabilities of ongoing clinical pregnancy, abortion, and ectopic pregnancy were examined by logistic regression adjusting for age, BMI, and baseline E2 level
  5. *Indicates significant difference between group B and group C, P < 0.017; chi-square test with Bonferroni correction