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Table 3 MMP and TIMP activities in the follicular fluid between the high and low percentage successful fertilization groups

From: Matrix metalloproteinase 2 level in human follicular fluid is a reliable marker of human oocyte maturation in in vitro fertilization and intracytoplasmic sperm injection cycles

Ā 

High fertility rate group (2PNā€‰ā‰„ā€‰70Ā %)

Low fertility rate group (2PNā€‰<ā€‰70Ā %)

P value

Number of patients

84

66

Ā 

Estradiol (pg/ml)

2689ā€‰Ā±ā€‰1588

2707ā€‰Ā±ā€‰1611

NS

Progesterone (ng/ml)

0.72ā€‰Ā±ā€‰0.49

0.74ā€‰Ā±ā€‰0.60

NS

MII oocytes ratio (%)

95.2ā€‰Ā±ā€‰11.9

88.3ā€‰Ā±ā€‰16.3

< 0.01

2PN embryos ratio (%)

88.5ā€‰Ā±ā€‰11.0

49.6ā€‰Ā±ā€‰18.1

< 0.001

D5 GB embryos ratio (%)

42.8ā€‰Ā±ā€‰33.4

26.6ā€‰Ā±ā€‰32.5

< 0.01

MMP-2 (Arbitrary units/Ī¼l)

19.4ā€‰Ā±ā€‰4.2

17.5ā€‰Ā±ā€‰4.6

< 0.01

MMP-9 (Arbitrary units/Ī¼l)

2.14ā€‰Ā±ā€‰0.70

2.10ā€‰Ā±ā€‰0.59

NS

TIMP-1 (ng/ml)

117ā€‰Ā±ā€‰32

120ā€‰Ā±ā€‰35

NS

TIMP-2 (ng/ml)

55.1ā€‰Ā±ā€‰15.1

53.2ā€‰Ā±ā€‰17.0

NS

  1. MII Metaphase II, 2PN Two pronuclei, D5 GB Good-quality blastocysts on day 5, MMP Matrix metalloproteinase, TIMP Tissue inhibitor of matrix metalloproteinase
  2. Values are expressed as the meanā€‰Ā±ā€‰SD. P values are comparisons between the high and low percentage successful fertilization groups by ANOVA. NS: no statistical significance (i.e., Pā€‰>ā€‰0.05)