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Table 3 MMP and TIMP activities in the follicular fluid between the high and low percentage successful fertilization groups

From: Matrix metalloproteinase 2 level in human follicular fluid is a reliable marker of human oocyte maturation in in vitro fertilization and intracytoplasmic sperm injection cycles

  High fertility rate group (2PN ≥ 70 %) Low fertility rate group (2PN < 70 %) P value
Number of patients 84 66  
Estradiol (pg/ml) 2689 ± 1588 2707 ± 1611 NS
Progesterone (ng/ml) 0.72 ± 0.49 0.74 ± 0.60 NS
MII oocytes ratio (%) 95.2 ± 11.9 88.3 ± 16.3 < 0.01
2PN embryos ratio (%) 88.5 ± 11.0 49.6 ± 18.1 < 0.001
D5 GB embryos ratio (%) 42.8 ± 33.4 26.6 ± 32.5 < 0.01
MMP-2 (Arbitrary units/μl) 19.4 ± 4.2 17.5 ± 4.6 < 0.01
MMP-9 (Arbitrary units/μl) 2.14 ± 0.70 2.10 ± 0.59 NS
TIMP-1 (ng/ml) 117 ± 32 120 ± 35 NS
TIMP-2 (ng/ml) 55.1 ± 15.1 53.2 ± 17.0 NS
  1. MII Metaphase II, 2PN Two pronuclei, D5 GB Good-quality blastocysts on day 5, MMP Matrix metalloproteinase, TIMP Tissue inhibitor of matrix metalloproteinase
  2. Values are expressed as the mean ± SD. P values are comparisons between the high and low percentage successful fertilization groups by ANOVA. NS: no statistical significance (i.e., P > 0.05)