Fig. 3

Lipoprotein receptor expression patterns in prostate cancer (high grade and low grade). Histologic staining for LDLR and SR-BI in selected patients. Tissue derived from a 27-year-old patient diagnosed with prostate hyperplasia was stained for LDLR (a); a consecutive area of the same tumor was stained for SR-BI (b). Tissue derived from a 75-year-old patient diagnosed with prostate cancer T2N1M1c and Gleason score 5 + 4 was stained for LDLR (c); a consecutive area of the same tumor was stained for SR-BI (d). Tumor biopsies from a 72-year-old patient diagnosed with prostate cancer T2N0M0 and Gleason score 3 + 3 were analyzed for SR-BI expression (e and f). Black arrows indicate clusters of cells strongly positive for SR-BI. Kaplan Meier analysis of LDLR and SR-BI expression in GSE40272 (g–h). High LDLR expression had no effect on disease-free survival time (g). High SR-BI expression was associated with decreased disease-free survival time (h). Green = high expression (high), blue = low expression (low), DFS = disease-free survival time. P-values of the log-rank test are presented within each graph