Maximum basal FSH predicts reproductive outcome better than cycle-specific basal FSH levels: waiting for a “better

Gingold, Julian A.; Lee, Joseph A.; Whitehouse, Michael C.; Rodriguez-Purata, Jorge; Sandler, Benjamin; Grunfeld, Lawrence; Mukherjee, Tanmoy; Copperman, Alan B.

doi:10.1186/s12958-015-0078-0

Table 3 Individual association of cycle parameters with BAFC and MII count

From: Maximum basal FSH predicts reproductive outcome better than cycle-specific basal FSH levels: waiting for a “better" month conveys limited retrieval benefits

		BAFC			MII Count
Parameter	Compared With	Odds Ratio	95 % CI	Sig.	Odds Ratio	95 % CI	Sig.
Age Group B	Age Group A	0.80	[0.75,0.84]	***	0.84	[0.79,0.89]	***
Age Group C	Age Group A	0.68	[0.64,0.72]	***	0.73	[0.69,0.77]	***
Age Group D	Age Group A	0.60	[0.56,0.64]	***	0.64	[0.60,0.69]	***
Age Group E	Age Group A	0.54	[0.51,0.58]	***	0.53	[0.48,0.58]	***
Downregulation Protocol	Antagonist Protocol	1.37	[1.28,1.47]	***	1.16	[1.09,1.23]	***
Microflare Protocol	Antagonist Protocol	0.70	[0.67,0.73]	***	0.72	[0.68,0.76]	***
IVF Cycle 2	IVF Cycle 1	1.00	[0.96,1.04]		0.94	[0.91,0.97]	***
IVF Cycle 3	IVF Cycle 1	0.99	[0.93,1.06]		0.96	[0.91,1.01]
IVF Cycle 4	IVF Cycle 1	0.97	[0.90,1.05]		0.98	[0.91,1.05]
IVF Cycle 5+	IVF Cycle 1	0.95	[0.86,1.06]		0.88	[0.79,1.00]	*
Previous MII Count	Per Oocyte	1.04	[1.03,1.04]	***	1.04	[1.04,1.05]	***
E2 Surge Level	Per 1000 pg/mL	1.21	[1.19,1.23]	***	1.40	[1.37,1.42]	***
Previous E2 Surge Level	Per 1000 pg/mL	1.22	[1.18,1.27]	***	1.28	[1.24,1.32]	***
Total Gonadotropin Dosage	Per 1000 IU	0.77	[0.75,0.78]	***	0.82	[0.81,0.83]	***
Previous Total Gonadotropin Dosage	Per 1000 IU	0.80	[0.78,0.83]	***	0.86	[0.84,0.88]	***
AMH	Per 1 ng/mL	1.07	[1.04,1.10]	***	1.09	[1.05,1.12]	***
Max FSH	Per 1 mIU/mL	0.93	[0.93,0.94]	***	0.91	[0.91,0.92]	***
PMax FSH	Per 1 mIU/mL	0.94	[0.93,0.95]	***	0.92	[0.91,0.93]	***
Current FSH	Per 1 mIU/mL	0.98	[0.97,0.98]	***	0.95	[0.94,0.96]	***
Max FSH Observed 1 Month Ago	0 Months Ago	0.98	[0.92,1.04]		1.11	[1.05,1.17]	***
Max FSH Observed 2 Months Ago	0 Months Ago	0.98	[0.91,1.06]		1.06	[0.99,1.14]
Max FSH Observed 2-6 Months Ago	0 Months Ago	0.97	[0.92,1.02]		1.06	[1.00,1.11]
Max FSH Observed >6 Months Ago	0 Months Ago	1.01	[0.95,1.07]		1.07	[1.01,1.13]	*

A GEE model controlling for patient and cycle number was constructed to test the association of multiple clinical parameters with BAFC or MII count. Association was noted as odds ratio (OR) with 95 % confidence intervals. Model significance was noted as *** (p<0.001) or * (p<0.05)

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