Progesterone elevation on the day of human chorionic gonadotropin administration adversely affects the outcome of IVF with transferred embryos at different developmental stages

Table 6 Comparison of demographic and clinical characteristics between subgroups of the day 5 ET group

Parameter^a	Serum P levels (ng/ml), day 5 ET		P-value*
	<1.75	≥1.75
No. of fresh cycles	1066	80
Female age (years)	29.5 ± 4.4	31.5 ± 5.2	0.002
BMI (kg/m²)	22.60 ± 3.31	21.95 ± 2.59	0.036
Basal FSH (IU/L)	6.61 ± 1.57	6.53 ± 1.83	NS
Total dose of Gn (IU)	1760.0 ± 635.5	2114.1 ± 680.7	<0.001
Serum E2 (pg/ml), hCG day	7583.3 ± 2595.8	9200.6 ± 3038.1	<0.001
Serum LH (IU/L), hCG day	1.6 ± 0.7	1.5 ± 0.7	NS
Endometrial thickness (mm), hCG day	12.2 ± 2.3	12.1 ± 2.5	NS
No. of oocytes retrieved	17.9 ± 5.0	19.7 ± 4.9	0.003
No. of 2PN oocytes	13.1 ± 3.8	14.4 ± 4.3	0.014
No. of 2PN cleavage embryos	12.9 ± 3.8	14.2 ± 4.3	0.003
No. of available embryos	9.7 ± 3.8	9.9 ± 4.8	0.031
Fertilization rate (%)	74.4	73.5	NS
Cleavage rate (%)	98.5	99.1	NS
No. of transferred embryos	1.08 ± 0.27	1.19 ± 0.39	0.017
ET with top-quality blastocyst (%)	58.7	52.7	NS
Implantation rate (%)	46.2	29.5	0.002
CPR (%)	41.4	21.3	<0.001

Note: Day 5 ET subgroups according progesterone cut-off levels: <1.75 ng/ml, ≥1.75 ng/ml; NS = not statistically significant
^aAll values are presented as the mean ± SD or count (%)
*Differences between subgroups were determined using Student’s t-test or the Mann–Whitney U test for continuous variables and the chi-square test or Fisher’s exact test for categorical variables

ISSN: 1477-7827