No association between polymorphisms in PTEN and primary ovarian insufficiency in a Han Chinese population

Table 4 The association analysis of the seven SNPs among the primary amenorrhea, secondary amenorrhea and control groups

SNP	Genotypes, n				Value	p	Alleles		Value	P	Bonferroni correction
rs1234219	T/T	T/C	C/C	Missing			T	C
Primary amenorrhea	19	3	0	0	0.659	0.989	41	3	0.093	0.976	1.000
Secondary amenorrhea	105	20	1	0			230	22
Controls	191	34	2	3			416	38
rs1903858	C/C	C/T	T/T	Missing			C	T
Primary amenorrhea	3	14	5	0	7.452	0.114	20	24	4.883	0.087	0.609
Secondary amenorrhea	44	56	26	0			144	108
Controls	55	112	59	4			222	230
rs2299939	C/C	C/A	A/A	Missing			C	A
Primary amenorrhea	19	3	0	0	6.694	0.132	41	3	6.346	0.042	0.294
Secondary amenorrhea	87	36	2	1			210	40
Controls	146	67	13	4			359	93
rs35352882	T/T	T/C	C/C	Missing			T	C
Primary amenorrhea	20	2	0	0	0.179	1.000	42	2	0.180	0.956	1.000
Secondary amenorrhea	115	11	0	0			241	11
Controls	207	19	0	4			433	19
rs17107001	G/G	G/T	T/T	Missing			G	T
Primary amenorrhea	21	1	0	0	0.478	0.832	43	1	0.451	0.835	1.000
Secondary amenorrhea	116	10	0	0			242	10
Controls	212	14	0	4			438	14
rs2299941	A/A	A/G	G/G	Missing			A	G
Primary amenorrhea	9	11	2	0	1.205	0.886	29	15	0.774	0.679	1.000
Secondary amenorrhea	47	61	18	0			155	97
Controls	96	100	30	4			292	160
rs12572106	T/T	T/C	C/C	Missing			T	C
Primary amenorrhea	7	13	2	0	4.244	0.370	27	17	2.766	0.251	1.000
Secondary amenorrhea	40	58	28	0			138	114
Controls	87	102	37	4			276	176

The allele and genotype frequencies among the primary amenorrhea, secondary amenorrhea and control groups were performed with Pearson’s chi-squared test or Fisher’s exact test using SPSS 13.0 software. There was no statistically significant difference in the allelic and genotypic distributions between the primary amenorrhea, secondary amenorrhea and control groups after Bonferroni correction

ISSN: 1477-7827