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Table 4 The association analysis of the seven SNPs among the primary amenorrhea, secondary amenorrhea and control groups

From: No association between polymorphisms in PTEN and primary ovarian insufficiency in a Han Chinese population

SNP Genotypes, n Value p Alleles Value P Bonferroni correction
rs1234219 T/T T/C C/C Missing    T C    
Primary amenorrhea 19 3 0 0 0.659 0.989 41 3 0.093 0.976 1.000
Secondary amenorrhea 105 20 1 0    230 22    
Controls 191 34 2 3    416 38    
rs1903858 C/C C/T T/T Missing    C T    
Primary amenorrhea 3 14 5 0 7.452 0.114 20 24 4.883 0.087 0.609
Secondary amenorrhea 44 56 26 0    144 108    
Controls 55 112 59 4    222 230    
rs2299939 C/C C/A A/A Missing    C A    
Primary amenorrhea 19 3 0 0 6.694 0.132 41 3 6.346 0.042 0.294
Secondary amenorrhea 87 36 2 1    210 40    
Controls 146 67 13 4    359 93    
rs35352882 T/T T/C C/C Missing    T C    
Primary amenorrhea 20 2 0 0 0.179 1.000 42 2 0.180 0.956 1.000
Secondary amenorrhea 115 11 0 0    241 11    
Controls 207 19 0 4    433 19    
rs17107001 G/G G/T T/T Missing    G T    
Primary amenorrhea 21 1 0 0 0.478 0.832 43 1 0.451 0.835 1.000
Secondary amenorrhea 116 10 0 0    242 10    
Controls 212 14 0 4    438 14    
rs2299941 A/A A/G G/G Missing    A G    
Primary amenorrhea 9 11 2 0 1.205 0.886 29 15 0.774 0.679 1.000
Secondary amenorrhea 47 61 18 0    155 97    
Controls 96 100 30 4    292 160    
rs12572106 T/T T/C C/C Missing    T C    
Primary amenorrhea 7 13 2 0 4.244 0.370 27 17 2.766 0.251 1.000
Secondary amenorrhea 40 58 28 0    138 114    
Controls 87 102 37 4    276 176    
  1. The allele and genotype frequencies among the primary amenorrhea, secondary amenorrhea and control groups were performed with Pearson’s chi-squared test or Fisher’s exact test using SPSS 13.0 software. There was no statistically significant difference in the allelic and genotypic distributions between the primary amenorrhea, secondary amenorrhea and control groups after Bonferroni correction