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Table 3 E2 and FSH concentrations in the three age groups, classified according to follicle size

From: Changes in estrone and estradiol levels during follicle development: a retrospective large-scale study

Diameter of the largest follicle Serum E2 (pg/mL) measured by iE2 reagent Serum FSH (mIU/mL)
(n = 9088) (n = 9088)
  Age <38 year Age 38–40 year Age >40 year Age <38 year Age 38–40 year Age >40 year
11 mm 68.0 ± 34.7a 71.0 ± 40.4a 86.8 ± 51.8a 8.6 ± 2.4b 9.5 ± 4.6 10.9 ± 6.8b
12 mm 80.4 ± 41.8a 84.7 ± 42.9a 102.8 ± 53.5a 8.4 ± 2.4a 8.8 ± 3.0a 11.1 ± 7.1a
13 mm 87.3 ± 42.6a 96.7 ± 44.6a 116.1 ± 61.2a 7.9 ± 2.3a 8.3 ± 3.2a 10.3 ± 7.0a
14 mm 100.3 ± 51.7c 115.8 ± 58.6c 126.1 ± 64.0c 7.4 ± 1.9c 8.5 ± 3.5c 9.9 ± 8.5c
15 mm 132.6 ± 64.2d 150.2 ± 66.5d 170.6 ± 76.5d 7.3 ± 2.3c 8.3 ± 3.7c 8.8 ± 4.3c
16 mm 160.0 ± 77.9a 177.0 ± 78.2a 197.4 ± 79.5a 7.1 ± 2.5a 7.7 ± 3.6a 9.0 ± 5.2a
17 mm 200.2 ± 85.7b 216.5 ± 78.5 222.3 ± 86.6b 6.8 ± 2.2d 7.7 ± 3.1d 8.8 ± 6.0d
18 mm 229.2 ± 85.4b 233.5 ± 88.9 247.0 ± 82.2b 6.6 ± 2.3d 7.2 ± 2.8d 8.5 ± 5.1d
19 mm 249.6 ± 78.0 256.0 ± 79.5 261.0 ± 83.5 6.3 ± 2.3a 6.8 ± 2.3a 8.3 ± 6.4a
20 mm 275.6 ± 95.2 285.1 ± 88.0 280.6 ± 92.0 6.5 ± 2.2a 6.8 ± 2.3a 7.8 ± 4.0a
  1. Data are presented as mean ± standard deviation
  2. aSignificant differences were found between the <38 year group and the >40 year group, as well as between the 38–40 year group and the >40 year group (P < 0.01)
  3. bSignificant differences were found between the <38 year group and the >40 year group (P < 0.01)
  4. cSignificant differences were found between the <38 year group and the 38–40 year group, as well as between the <38 year group and the >40 year group (P < 0.01)
  5. dSignificant differences were found among all three age groups (P < 0.01)
  6. E2 estradiol, FSH follicle-stimulating hormone, iE2 reagent ST AIA-PACK iE2 reagent