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Table 1 Patient and IVF cycle characteristics of 98 euthyroid women suffering from diminished ovarian function and their 431 embryos according to TSH levels

From: The impact of thyroid function and thyroid autoimmunity on embryo quality in women with low functional ovarian reserve: a case-control study

 

All

TSH ≤2.5μIU/mL

TSH >2.5μIU/mL

(n = 98/431)

(n = 77/330)

(n = 21/101)

Female age (years)

39.6 ± 4.6

39.8 ± 4.5

38.8 ± 5.1

Baseline FSH (IU/mL)

11.4 ± 6.6

11.6 ± 6.9

10.5 ± 5.2

AMH (ng/mL)

0.8 ± 0.8

0.8 ± 0.8

0.8 ± 0.7

TSH (μIU/mL)

1.8 ± 0.9

1.5 ± 0.5

3.1 ± 0.4

Thyroid autoimmunity (%)

17.3 %

11.7 %*

38.1 %*

Thyroid peroxidase antibodies (%)

13.3 %

9.1 %**

28.6 %**

Thyroglubulin antibodies (%)

9.2 %

7.8 %

14.3 %

Thyroid receptor antibodies (%)

2.0 %

2.6 %

4.8 %

Total gonadotrophin dosage (IU)

6593.6 ± 2579.7

6613.3 ± 2599.2

6521.4 ± 2568.3

Number of oocytes retrieved

6.7 ± 4.4

6.7 ± 4.5

7.1 ± 3.7

Number of embryos transferred

2.6 ± 1.0

2.5 ± 1.0

2.7 ± 1.1

Good quality embryos (n, %)

203 (47.1 %)

152 (46.1 %)

51 (50.5 %)

Fair quality embryos (n, %)

183 (42.5 %)

141 (42.7 %)

42 (41.6 %)

Poor quality embryos (n, %)

45 (10.4 %)

37 (11.2 %)

8 (7.9 %)

Clinical pregnancy rate (%)

20.7 %

22.2 %

15.0 %

Live birth rate (%)

13.0 %

13.9 %

5.0 %

  1. Values are presented as means ± SD
  2. More than one thyroid antibody may be present in women with thyroid autoimmunity. Thus, percentages of the various thyroid antibodies may not add up to 100 %. Baseline and cycle characteristics are not statistically different between groups, if not indicated
  3. *P = 0.015,**P = 0.003