Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases

Table 1 Relation of male infertility (UMLS ID: C0021364) with other diseases that significantly share GWAS/OMIM/DEG genes [5]

Diseases	P value ^a
Infertility	<0.0001
Mutation abnormality	0.0004
Malignant neoplasm of urinary organ, unspecified	0.0010
Bladder neoplasm	0.0010
Urologic neoplasms	0.0010
Carcinoma of bladder	0.0010
Neoplasm of unspecified nature of bladder	0.0010
Urinary bladder diseases	0.0011
B cell lymphomas	0.0029
Liposarcoma, myxoid	0.0036
Liposarcoma	0.0037
Neoplasms, fibrous tissue	0.0042
Juvenile dermatomyositis	0.0044
Amyopathic dermatomyositis	0.0044
Fibrosarcoma	0.0044
Neoplasms, connective tissue	0.0050
Liposarcoma, dedifferentiated	0.0058
Frontotemporal lobar degeneration	0.0074
Lymphoma, non Hodgkin	0.0077
TDP 43 proteinopathies	0.0098
Myositis	0.0099

^aA hypergeometric test was applied by DiseaseConnect [5] to assess the significance of the GWAS/OMIM/DEG genes shared by male infertility and a particular disease.

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