Hormonal, follicular and endometrial dynamics in letrozole-treated versus natural cycles in patients undergoing controlled ovarian stimulation

Table 1 Study demographics

	Group I (Natural cycle)	Group II (letrozole 2.5 mg)	Group III (letrozole 5 mg)	P value
Total No of patients	47	125	36
Age (Mean ± SD)	34.8 ± 5.03	33.5 ± 4.02	33.88 ± 3.45	NS
Day 3 FSH (IU/L)	6.01 ± 1.71	6.47 ± 2.16	7.49 ± 3.76	I VsII: 0.233 I VsIII: 0.033
Total No of cycles started	71	179	50
Completed cycle: No, [%]	63 [88.7]	142 [79.3]	43 [86]
Total number of cycles cancelled: No, [%]	8 [11.3]	37 [20.7]	7 [14]	0,06
No of monitoring visits (Mean ±SD)	2.08 ± 1.02	2.3 ± 1.12	2.68 ± 1.11	I VsII: 0.232 I VsIII: 0.003
Causes of cycle cancelling
Poor responder: No, [%]	5 [62.5]	9 [24.3]	0 [0]	NS
Ovarian cyst: No, [%]	0 [0]	16 [43.2]	2 [28.6]	NS
Patient request: No, [%]	1 [12.5]	8 [21.6]	0 [0]	NS
Elevated FSH: No, [%]	0 [0]	2 [5.4]	3 [42.9]	NS
Others: No, [%]	2 [25]	2 [5.4]	2 [28.6]	NS
Indication for IUI
Male factor infertility: No, [%]	38/71 [53.5]	55/179 [30.7]	19/50 [38]	NS
Unexplained infertility: No, [%]	33/71 [46.5]	106/179 [59.3]	30/50 [60]	NS
Endometriosis: No, [%]	0 [0]	9/179 [5]	0 [0]	NS
Others No, [%]	1/71 [1.4]	9/179 [5]	1 [2]	NS

ISSN: 1477-7827