|
Reference
|
Mean GA
|
Outcome
|
Cases (Preeclampsia)
|
Controls (normotensive)
|
P-value
|
% difference†
|
|---|
| | | |
n
|
Flt-1 concentration
|
n
|
sFlt-1 concentration
| | |
|---|
|
Studies reporting mean concentrations
|
mean, SD/SE
| |
mean, SD/SE
| | |
|
Baumann, 2008
|
12.3
|
PE (> 34 weeks)
|
46
|
1764 (757)
|
92
|
1537 (812)
|
0.04
|
+13
|
|
Chaiworapongsa, 2005
|
12.3
|
PE
|
34
|
546 (271)
|
37
|
464 (260)
|
0.10
|
+15
|
|
Lynch, 2010
|
12.3
|
PE
|
31
|
1374 (639)
|
637
|
1313 (521)
|
0.5
|
+5
|
|
Noori, 2010
|
13.7
|
PE (< 37 weeks)
|
10
|
2414 (622)
|
128
|
1729 (85)
|
< 0.01
|
+40
|
| | |
PE (≥ 37 weeks)
|
10
|
1688 (210)
|
128
|
1729 (85)
|
0.19
|
- 2
|
|
Rana S, 2007
|
11-13*
|
PE
|
39
|
3500 (300)
|
147
|
3000 (100)
|
0.14
|
+14
|
|
Thadhani, 2004
|
10.7
|
PE
|
40
|
1048 (657)
|
80
|
973 (490)
|
> 0.05
|
+ 7
|
|
Vatten, 2007
|
9.0
|
Preterm PE
|
110
|
135
|
276
|
166
|
0.01
|
-19
|
|
Studies reporting median concentrations
|
median
| |
median
| | |
|
Akolekar 2010
|
11-13*
|
PE (< 34 weeks)
|
30
|
7099
|
180
|
6349
|
NS
|
+12
|
| | |
PE (≥ 34 weeks)
|
60
|
6840
|
180
|
6349
|
NS
|
+ 8
|
|
Erez, 2008
|
12.2
|
PE (< 37 weeks)
|
17
|
1308
|
201
|
1788
|
0.03
|
-27
|
| |
12.2
|
PE (≥ 37 weeks)
|
39
|
1448
|
201
|
1788
|
0.02
|
-19
|
|
Wathen, 2006
|
13.7
|
PE
|
44
|
481
|
51
|
432
|
> 0.05
|
+10
|
- *No mean gestational age (GA) provided
- † % difference in case mean or median 1st trimester sFLT-1 compared with the control level
