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Table 3 Results from studies assessing the association between 1st trimester sFlt-1 concentrations (pg/mL) and preeclampsia (PE)

From: Levels of soluble fms-like tyrosine kinase one in first trimester and outcomes of pregnancy: a systematic review

Reference Mean GA Outcome Cases (Preeclampsia) Controls (normotensive) P-value % difference†
    n Flt-1 concentration n sFlt-1 concentration   
Studies reporting mean concentrations mean, SD/SE   mean, SD/SE   
Baumann, 2008 12.3 PE (> 34 weeks) 46 1764 (757) 92 1537 (812) 0.04 +13
Chaiworapongsa, 2005 12.3 PE 34 546 (271) 37 464 (260) 0.10 +15
Lynch, 2010 12.3 PE 31 1374 (639) 637 1313 (521) 0.5 +5
Noori, 2010 13.7 PE (< 37 weeks) 10 2414 (622) 128 1729 (85) < 0.01 +40
   PE (≥ 37 weeks) 10 1688 (210) 128 1729 (85) 0.19 - 2
Rana S, 2007 11-13* PE 39 3500 (300) 147 3000 (100) 0.14 +14
Thadhani, 2004 10.7 PE 40 1048 (657) 80 973 (490) > 0.05 + 7
Vatten, 2007 9.0 Preterm PE 110 135 276 166 0.01 -19
Studies reporting median concentrations median   median   
Akolekar 2010 11-13* PE (< 34 weeks) 30 7099 180 6349 NS +12
   PE (≥ 34 weeks) 60 6840 180 6349 NS + 8
Erez, 2008 12.2 PE (< 37 weeks) 17 1308 201 1788 0.03 -27
  12.2 PE (≥ 37 weeks) 39 1448 201 1788 0.02 -19
Wathen, 2006 13.7 PE 44 481 51 432 > 0.05 +10
  1. *No mean gestational age (GA) provided
  2. † % difference in case mean or median 1st trimester sFLT-1 compared with the control level