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Table 3 Predicted geometric mean (G1) hormone concentration in men by tertiles of right and left 2D:4D and Δr-l.

From: Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood

  

Right Hand

Left Hand

Δr-l

2D:4D tertile

G

(95% CI)

P 2 trend

ρ 3

P 4

G

(95% CI)

P 2 trend

ρ 3

P 4

G

(95% CI)

P 2 trend

ρ 3

P 4

Testosterone (nmol/l)

I

15.9

(15.3 - 16.4)

0.04

-0.05

0.12

15.6

(15.0 - 16.2)

0.34

-0.03

0.34

15.5

(14.9 - 16.0)

0.86

-0.02

0.44

 

II

15.3

(14.8 - 15.9)

   

15.3

(14.7 - 15.8)

   

15.3

(14.7 - 15.8)

   
 

III

15.0

(14.5 - 15.6)

   

15.2

(14.7 - 15.8)

   

15.4

(14.9 - 16.0)

   

Free testosterone (pmol/l)

I

242.1

(232.1 - 252.0)

0.07

-0.04

0.19

237.4

(227.7 - 247.2)

0.50

-0.02

0.51

236.6

(226.8 - 246.4)

0.81

-0.03

0.42

 

II

233.5

(224.0 - 243.0)

   

232.8

(223.3 - 242.3)

   

232.8

(223.2 - 242.4)

   
 

III

229.1

(219.7 - 238.6)

   

232.7

(223.1 - 242.3)

   

234.9

(225.2 - 244.6)

   

Oestradiol (pmol/l)

I

104.3

(99.6 - 108.9)

0.73

0.02

0.45

104.5

(99.8 - 109.2)

0.83

0.02

0.41

104.4

(99.8 - 109.1)

0.84

-0.00

0.96

 

II

105.6

(100.9 - 110.3)

   

105.3

(100.6 - 109.9)

   

105.7

(101.0 - 110.5)

   
 

III

105.0

(100.3 - 109.7)

   

104.9

(100.3 - 109.6)

   

104.9

(100.2 - 109.6)

   

Free oestradiol (pmol/l)

I

1.7

(1.6 - 1.8)

0.51

0.03

0.31

1.7

(1.6 - 1.8)

0.58

0.03

0.26

1.7

(1.6 - 1.8)

0.92

-0.00

0.99

 

II

1.7

(1.7 - 1.8)

   

1.7

(1.6 - 1.8)

   

1.7

(1.7 - 1.8)

   
 

III

1.7

(1.6 - 1.8)

   

1.7

(1.6 - 1.8)

   

1.7

(1.6 - 1.8)

   

DHEAS (μmol/l)

I

3.3

(3.1 - 3.5)

0.37

-0.03

0.28

3.4

(3.2 - 3.6)

0.07

-0.04

0.13

3.3

(3.1 - 3.5)

0.68

0.01

0.64

 

II

3.4

(3.2 - 3.6)

   

3.2

(3.0 - 3.4)

   

3.2

(3.0 - 3.4)

   
 

III

3.2

(3.0 - 3.4)

   

3.2

(3.0 - 3.3)

   

3.4

(3.2 - 3.6)

   

Androstenedione (nmol/l)

I

4.2

(3.9 - 4.4)

0.30

-0.05

0.12

4.2

(4.0 - 4.4)

0.31

-0.04

0.26

4.2

(4.0 - 4.4)

0.96

-0.02

0.52

 

II

4.2

(3.9 - 4.4)

   

4.2

(3.9 - 4.4)

   

4.0

(3.8 - 4.2)

   
 

III

4.0

(3.8 - 4.2)

   

4.0

(3.8 - 4.2)

   

4.2

(4.0 - 4.4)

   

Androstenediol glucoronide (ng/ml)

I

13.9

(13.0 - 14.8)

0.11

0.05

0.11

14.0

(13.2 - 14.9)

0.32

0.03

0.32

14.2

(13.3 - 15.1)

0.49

0.02

0.57

 

II

14.3

(13.4 - 15.2)

   

14.4

(13.5 - 15.3)

   

14.2

(13.4 - 15.1)

   
 

III

14.8

(13.9 - 15.7)

   

14.6

(13.7 - 15.5)

   

14.6

(13.7 - 15.5)

   

SHHB (nmol/l)

I

35.0

(33.6 - 36.3)

0.50

-0.02

0.57

34.7

(33.4 - 36.0)

0.60

-0.02

0.60

34.5

(33.2 - 35.8)

0.98

-0.01

0.82

 

II

33.9

(32.6 - 35.2)

   

34.0

(32.8 - 35.3)

   

34.0

(32.7 - 35.3)

   
 

III

34.3

(33.0 - 35.6)

   

34.2

(33.0 - 35.5)

   

34.5

(33.2 - 35.8)

   
  1. 1Estimates from linear mixed models of the logarithm of hormone concentration on 2D:4D tertiles with laboratory batch entered as a random intercept, adjusted for ethnicity, age at blood draw, BMI, and smoking status.
  2. 2From likelihood ratio test for linear trend across 2D:4D tertiles.
  3. 3Standardised regression coefficients (correlations) from linear mixed models of the logarithm of hormone concentration on continuous 2D:4D with laboratory batch entered as a random intercept, adjusted for ethnicity, age at blood draw, BMI, and smoking status.
  4. 4From likelihood ratio test of ρ.
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Reproductive Biology and Endocrinology

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