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Table 3 Predicted geometric mean (G1) hormone concentration in men by tertiles of right and left 2D:4D and Δr-l.

From: Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood

   Right Hand Left Hand Δr-l
2D:4D tertile G (95% CI) P 2 trend ρ 3 P 4 G (95% CI) P 2 trend ρ 3 P 4 G (95% CI) P 2 trend ρ 3 P 4
Testosterone (nmol/l) I 15.9 (15.3 - 16.4) 0.04 -0.05 0.12 15.6 (15.0 - 16.2) 0.34 -0.03 0.34 15.5 (14.9 - 16.0) 0.86 -0.02 0.44
  II 15.3 (14.8 - 15.9)     15.3 (14.7 - 15.8)     15.3 (14.7 - 15.8)    
  III 15.0 (14.5 - 15.6)     15.2 (14.7 - 15.8)     15.4 (14.9 - 16.0)    
Free testosterone (pmol/l) I 242.1 (232.1 - 252.0) 0.07 -0.04 0.19 237.4 (227.7 - 247.2) 0.50 -0.02 0.51 236.6 (226.8 - 246.4) 0.81 -0.03 0.42
  II 233.5 (224.0 - 243.0)     232.8 (223.3 - 242.3)     232.8 (223.2 - 242.4)    
  III 229.1 (219.7 - 238.6)     232.7 (223.1 - 242.3)     234.9 (225.2 - 244.6)    
Oestradiol (pmol/l) I 104.3 (99.6 - 108.9) 0.73 0.02 0.45 104.5 (99.8 - 109.2) 0.83 0.02 0.41 104.4 (99.8 - 109.1) 0.84 -0.00 0.96
  II 105.6 (100.9 - 110.3)     105.3 (100.6 - 109.9)     105.7 (101.0 - 110.5)    
  III 105.0 (100.3 - 109.7)     104.9 (100.3 - 109.6)     104.9 (100.2 - 109.6)    
Free oestradiol (pmol/l) I 1.7 (1.6 - 1.8) 0.51 0.03 0.31 1.7 (1.6 - 1.8) 0.58 0.03 0.26 1.7 (1.6 - 1.8) 0.92 -0.00 0.99
  II 1.7 (1.7 - 1.8)     1.7 (1.6 - 1.8)     1.7 (1.7 - 1.8)    
  III 1.7 (1.6 - 1.8)     1.7 (1.6 - 1.8)     1.7 (1.6 - 1.8)    
DHEAS (μmol/l) I 3.3 (3.1 - 3.5) 0.37 -0.03 0.28 3.4 (3.2 - 3.6) 0.07 -0.04 0.13 3.3 (3.1 - 3.5) 0.68 0.01 0.64
  II 3.4 (3.2 - 3.6)     3.2 (3.0 - 3.4)     3.2 (3.0 - 3.4)    
  III 3.2 (3.0 - 3.4)     3.2 (3.0 - 3.3)     3.4 (3.2 - 3.6)    
Androstenedione (nmol/l) I 4.2 (3.9 - 4.4) 0.30 -0.05 0.12 4.2 (4.0 - 4.4) 0.31 -0.04 0.26 4.2 (4.0 - 4.4) 0.96 -0.02 0.52
  II 4.2 (3.9 - 4.4)     4.2 (3.9 - 4.4)     4.0 (3.8 - 4.2)    
  III 4.0 (3.8 - 4.2)     4.0 (3.8 - 4.2)     4.2 (4.0 - 4.4)    
Androstenediol glucoronide (ng/ml) I 13.9 (13.0 - 14.8) 0.11 0.05 0.11 14.0 (13.2 - 14.9) 0.32 0.03 0.32 14.2 (13.3 - 15.1) 0.49 0.02 0.57
  II 14.3 (13.4 - 15.2)     14.4 (13.5 - 15.3)     14.2 (13.4 - 15.1)    
  III 14.8 (13.9 - 15.7)     14.6 (13.7 - 15.5)     14.6 (13.7 - 15.5)    
SHHB (nmol/l) I 35.0 (33.6 - 36.3) 0.50 -0.02 0.57 34.7 (33.4 - 36.0) 0.60 -0.02 0.60 34.5 (33.2 - 35.8) 0.98 -0.01 0.82
  II 33.9 (32.6 - 35.2)     34.0 (32.8 - 35.3)     34.0 (32.7 - 35.3)    
  III 34.3 (33.0 - 35.6)     34.2 (33.0 - 35.5)     34.5 (33.2 - 35.8)    
  1. 1Estimates from linear mixed models of the logarithm of hormone concentration on 2D:4D tertiles with laboratory batch entered as a random intercept, adjusted for ethnicity, age at blood draw, BMI, and smoking status.
  2. 2From likelihood ratio test for linear trend across 2D:4D tertiles.
  3. 3Standardised regression coefficients (correlations) from linear mixed models of the logarithm of hormone concentration on continuous 2D:4D with laboratory batch entered as a random intercept, adjusted for ethnicity, age at blood draw, BMI, and smoking status.
  4. 4From likelihood ratio test of ρ.